Abstract
The (NZB×NZW)F1 hybrid mouse develops a severe autoimmune disease similar to systemic lupus erythematosus in humans. Both the human and murine form of the disease show strong associations with alleles of the major histocompatibility complex (MHC) gene products1,2. The severe form of the disease found in F1 mice is due, in part, to dominant NZW gene(s) mapping with the H-2 complex (the murine MHC). Here we present evidence that the tumour necrosis factor (TNF-α)gene, which is located within the H-2 complex (the murine major histocompatibility complex), could be involved in the pathogenesis of lupus nephritis in F1 mice. Thus, a restriction fragment length polymorphism in the TNF-α gene correlates with the reduced levels of TNF-α produced by NZW mice. Furthermore, replacement therapy with recombinant TNF-α induces a significant delay in the development of the nephritis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Reinertsen, J. L. et al. Nev. Engl. J. Med. 299, 515–518 (1978).
Knight, J. G. & Adams, D. D. J. exp. Med. 147, 1653–1660 (1978).
Howie, J. B. & Helyer, B. J. Adv. Immun. 9, 215–266 (1968).
Kelley, V. E. & Winkelstein, A. Clin. Immun. Immunopath. 16, 142–150 (1980).
Kotzin, B. L. & Palmer, E. J. exp. Med. 165, 1237–1251 (1987).
Jacob, C. O., Van Der Meide, P. H. & McDevitt, H. O. J. exp. Med. 166, 798–802, 1987.
Beutler, B. & Cerami, A. Nature 320, 584–588 (1986).
Newdin, G. E. et al. Nucleic Acids Res. 13, 6361–6373 (1985).
Nedospasov, S. A. et al. Nucleic Acids Res. 14, 7713–7725 (1986).
Muller, U., Jongeneel, C. V., Nedospasov, S. A., Fischer-Lindahl, K. & Steinmetz, M. Nature 325, 265–267, 1987.
Spies, T. et al. Proc. natn. Acad. Sci. U.S.A. 83, 8699–8703 (1986).
Pennica, D., Hayflick, J. S., Bringman, T. S., Palladino, M. A. & Goeddel, D. V. Proc. natn. Acad. Sci. U.S.A. 82, 6060–6064 (1985).
Li, C. B. et al. J. Immun. 138, 4496–4501 (1987).
Gardner, S. M., Mock, B. A., Hilgers, J., Huppi, K. E. & Roeder, W. D. J. Immun. 139, 476–483 (1987).
Mukavitz-Kramer, S. & Carver, M. E. J. immun. Meth. 93, 201–206 (1986).
Old, L. J. Nature 326, 330–331 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jacob, C., McDevitt, H. Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis. Nature 331, 356–358 (1988). https://doi.org/10.1038/331356a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/331356a0
This article is cited by
-
Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes
Clinical Reviews in Allergy & Immunology (2017)
-
Biologics for the treatment of autoimmune renal diseases
Nature Reviews Nephrology (2016)
-
TNF receptors: signaling pathways and contribution to renal dysfunction
Kidney International (2015)
-
Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus
Seminars in Immunopathology (2014)
-
Requirements for innate immune pathways in environmentally induced autoimmunity
BMC Medicine (2013)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.