Abstract
A specific protein, bound to DNA, can activate transcription of a wide array of genes in many eukaryotes. Further analysis suggests a general outline for how eukaryotic transcriptional activators function and are controlled.
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References
Ptashne, M. Nature 322, 697–701 (1986).
Ptashne, M. A Genetic Switch (Cell Press, Palo Alto, California & Blackwell Publishing, 1986).
Guarente, L., Nye, J. S., Hochschild, A. & Ptashne, M. Proc. natn. Acad. Sci. U.S.A. 79, 2236–2239 (1982).
Hochschild, A., Irwin, N. & Ptashne, M. Cell 32, 319–325 (1983).
Bushman, F. D. & Ptashne, M. Cell 54, 191–197 (1988).
Brent, R. & Ptashne, M. Cell 43, 729–736 (1985).
Keegan, L., Gill, G. & Ptashne, M. Science 231, 699–704 (1986).
Guarente, L., Yocum, R. & Gifford, P. Proc. natn. Acad. Sci. U.S.A. 79, 7410–7414 (1982).
West, R. W. Jr, Yocum, R. & Ptashne, M. Molec. cell. Biol. 4, 2467–2478 (1984).
Hope, I. A. & Struhl, K. Cell 43, 177–188 (1985).
Hope, I. A. & Struhl, K. Cell 46, 885–894 (1986).
Picard, D., Salser, S. J. & Yamamoto, K. Cell (in the press).
Ma, J. & Ptashne, M. Cell 48, 847–853 (1987).
Hope, I. A., Mahadevan, S. & Struhl, K. Nature 333, 635–640 (1988).
Gill, G. & Ptashne, M. Cell 51, 121–126 (1987).
Gill, G. & Ptashne, M. Nature 334, 721–724 (1988).
Ma, J. & Ptashne, M. Cell 51, 113–119 (1987).
Giniger, E. & Ptashne, M. Nature 330, 670–672 (1987).
Lech, K., Anderson, K. & Brent, R. Cell 52, 179–184 (1988).
Celenza, J. L. & Carlson, M. Science 233, 1175–1180 (1986).
Hoeffler, W. K., Kovelman, R. & Roeder, R. Cell 53, 907–920 (1988).
Sorger, P. K. & Pelham, H. R. B. Cell (in the press).
Godowski, P. J., Picard, D. & Yamamoto, K. R. Science 241, 812–816 (1988).
Webster, N., Green, S., Jin, J. J. & Chambon, P. Cell 54, 199–207 (1988).
Hollenberg, S. M. & Evans, R. Cell (submitted).
Schena, M. & Yamamoto, K. Science 241, 965–968 (1988).
Metzger, D., White, J. H. & Chambon, P. Nature 334, 31–36 (1988).
Fischer, J. A., Giniger, E., Maniatis, T. & Ptashne, M. Nature 332, 853–856 (1988).
Ma, J., Przibilla, E., Hu, J., Bogorad, L. & Ptashne, M. Nature 334, 631–633 (1988).
Kakidani, H. & Ptashne, M. Cell 52, 161–167 (1988).
Webster, N., Jin, J. R., Green, S., Hollis, M. & Chambon, P. Cell 52, 169–178 (1988).
Serfling, E., Jasin, M. & Schaflner, W. Trends Genet. 1, 224 (1985).
Sadowski, I., Ma, J., Triezenberg, S. & Ptashne, M. Nature (in the press).
Marsden, J. C. J. Virol. 61, 2428–2437 (1987).
Triezenberg, S. J., Kingsbury, R. C. & McKnight, S. L. Genes Dev. 2, 718–729 (1988).
Triezenberg, S. J., LaMarco, K. L. & McKnight, S. L. Genes Dev. 2, 730–742 (1988).
O'Hare, P. & Goding, C. R. Cell 52, 435–445 (1988).
Preston, C. M., Frame, M. C. & Campbell, M. E. M. Cell 52, 425–434 (1988).
McKnight, J. L. C., Kristie, T. M. & Roizman, B. Proc. natn. Acad. Sci. U.S.A. 84, 7061–7065 (1987).
Maniatis, T., Goodbourn, S. & Fischer, J. A. Science 236, 1237–1245 (1987).
Berk, A. J. A. Rev. Genet. 20, (eds Campbell, A., Herskowitz, I. & Sandber, L. M.) 45–81 (1986).
Random House Dictionary of the English Language (Random House, New York, 1967).
Struhl, K. Molec. cell. Biol. 6, 3847–3853 (1986).
Schaffner, A., Schirm, S., Muller-Baden, B., Welser, F. & Schaffner, W. J. molec. Biol. 201, 81–90 (1988).
Ondek, B., Gloss, L. & Herr, W. Nature 333, 40–45 (1988).
Herr, W. & Clarke, J. Cell 45, 461–470 (1986).
Davidson, I., Xiao, J. H., Rosales, R., Staub, A. & Chambon, P. Cell (in the press).
Fromental, C., Kanno, M., Nomiyama, H. & Chambon, P. Cell (in the press).
Giniger, E. & Ptashne, M. Proc. natn. Acad. Sci. U.S.A. 85, 382–386 (1988).
Lin, Y. S., Carey, M. F., Ptashne, M. & Green, M. R. Cell 54, 659–664 (1988).
Lee, K. A. W. et al. Proc. natn. Acad. Sci. U.S.A. 84, 8355–8359 (1987).
Sawadogo, M. & Roeder, R. G. Cell 43, 165–175 (1985).
Carthew, R. W., Chodosh, L. A. & Sharp, P. A. Cell 43, 439–448 (1985).
Sigler, P. B. Nature 333, 210–212 (1988).
Horikoshi, M., Hai, T., Lin, Y. S., Green, M. R. & Roeder, R. G. Cell (in the press).
Horikoshi, M., Carey, M. F., Kakidani, H. Roeder, R. G. Cell 54, 665–669 (1988).
Buratowski, S., Hahn, S., Sharp, P. A. & Guarente, L. Nature 334, 37–42 (1988).
Cavallini, B. et al. Nature 334, 77–80 (1988).
Fischer, J. A. & Maniatis, T. Cell 53, 451–461 (1988).
Denis, M., Poellinger, L., Wikstrom, A. C. & Gustafsson, J. A. Nature 333, 686–688 (1988).
Pratt, W. B. et al. J. biol. Chem. 263, 267–273 (1988).
Picard, D. & Yamamoto, K. EMBO J. 6, 3333 (1987).
Howard, K. J. & Distelhorst, C. W. J. biol. Chem. 263, 3474–3481 (1988).
Ma, J. & Ptashne, M. Cell 50, 137–142 (1987).
Johnston, S. A., Salmeron, J. M. Jr & Dincher, S. S. Cell 50, 143–146 (1987).
Lue, N. F., Chasmin, D. I., Buckman, A. R. & Kornberg, R. D. Molec. Cell. Biol. 7, 3446–3451 (1987).
Ma, J. & Ptashne, M. Cell (in the press).
Baeuerle, P. A. & Baltimore, D. Cell 53, 211–217 (1988).
Magasanik, B. TIBS (in the press).
Minchin, S. D., Austin, S. & Dixon, R. A. Molec. Microbiol. 2, 433–442 (1988).
Ninfa, A. J., Reitzer, L. J. & Magasanik, B. Cell 50, 1039–1046 (1987).
Keener, J. & Kustu, S. Proc. natn. Acad. Sci. U.S.A. 85, 4976–4980 (1988).
Helmann, J. D. & Chamberlin, M. J. A. Rev. Biochem. (in the press).
Hochschild, A. & Ptashne, M. Cell 44, 925–933 (1986).
Griffith, J., Hochschild, A. & Ptashne, M. Nature 322, 750–752 (1986).
Hochschild, A. & Ptashne, M. Nature (submitted).
Giniger, E., Varnum, S. M. & Ptashne, M. Cell 40, 767–774 (1985).
Bram, R. J. & Kornberg, R. D. Proc. natn. Acad. Sci. U.S.A. 82, 43–47 (1985).
Jencks, W. P. Proc. natn. Acad. Sci. U.S.A. 78, 4046–4050 (1981).
Sabbah, M., Reduilh, C., Secco, C. & Bauliue, E. E. J. biol. Chem. 262, 8631–8635 (1987).
Kumar, V. & Chambon, P. Cell (in the press).
Goute, C. & Johnson, A. D. Cell 52, 879–882 (1988).
Hollis, M., Valenzuela, D., Pioli, D., Wharton, R. & Ptashne, M. Proc. natn. Acad. Sci. U.S.A. 85, 5834–5838 (1988).
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Ptashne, M. How eukaryotic transcriptional activators work. Nature 335, 683–689 (1988). https://doi.org/10.1038/335683a0
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DOI: https://doi.org/10.1038/335683a0
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