Abstract
The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an a-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.
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Kodama, T., Freeman, M., Rohrer, L. et al. Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils. Nature 343, 531–535 (1990). https://doi.org/10.1038/343531a0
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DOI: https://doi.org/10.1038/343531a0
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