Humans have several ways of keeping cancer at bay, and the p53 protein forms a crucial part of this self-defence. The newly discovered action of a p53-binding protein helps explain how cells respond to p53.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines
Cancer Cell International Open Access 18 November 2013
-
Visualization and targeted disruption of protein interactions in living cells
Nature Communications Open Access 24 October 2013
-
Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction
International Journal of Peptide Research and Therapeutics Open Access 15 March 2006
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vogelstein, B., Lane, D. & Levine, A. J. Nature 408, 307–310 (2000).
Brent Derry, W., Putzke, A. P. & Rothman, J. H. Science 294, 591–595 (2001).
Samuels-Lev, Y. et al. Mol. Cell 8, 781–794 (2001).
Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R. & Fields, S. Proc. Natl Acad. Sci. USA 91, 6098–6102 (1994).
Gorina, S. & Pavletich, N. P. Science 274, 1001–1005 (1996).
Iwabuchi, K. et al. J. Biol. Chem. 273, 26061–26068 (1998).
Chen, X. et al. Genes Dev. 10, 2438–2451 (1996).
Smart, P. et al. Oncogene 18, 7378–7386 (1999).
Saller, E. et al. EMBO J. 18, 4424–4437 (1999).
Ludwig, R. T. et al. Mol. Cell. Biol. 16, 4952–4960 (1996).
Polyak, K. Genes Dev. 10, 1945–1952 (1996).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lane, D. How cells choose to die. Nature 414, 25–27 (2001). https://doi.org/10.1038/35102132
Issue Date:
DOI: https://doi.org/10.1038/35102132
This article is cited by
-
Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines
Cancer Cell International (2013)
-
Visualization and targeted disruption of protein interactions in living cells
Nature Communications (2013)
-
Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction
International Journal of Peptide Research and Therapeutics (2006)
-
Abnormal mRNA expression of ASPP members in leukemia cell lines
Leukemia (2004)
-
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
Nature (2002)
