Abstract
The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere.
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Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
Townsend, A. R. et al. Cell 44, 959–968 (1986).
Bjorkman, P. J. et al. Nature 329, 512–518 (1987).
Rötzschke, O. et al. Nature 348, 252–254 (1990).
Van Bleek, G. M. & Nathenson, S. G. Nature 348, 213–216 (1990).
Garrett, T. P. J., Saper, M. A., Bjorkman, P. J., Strominger, J. L. & Wiley, D. C. Nature 343, 692–696 (1989).
Rötzschke, O., Falk, K., Wallny, H.-J., Faath, S. & Rammensee, H.-G. Science 249, 283–287 (1990).
Falk, K., Rötzschke, O. & Rammensee, H.-G. Nature 348, 248–251 (1990).
Shimonkevitz, R., Kappler, J., Marrack, P. & Grey, H. J. exp. Med. 158, 303–316 (1983).
Demotz, S., Grey, H. M., Appella, E. & Sette, A. Nature 343, 682–684 (1989).
Bjorkman, P. J. et al. Nature 329, 506–512 (1987).
DeLisi, C. & Berzofsky, J. A. Proc. natn. Acad. Sci. U.S.A. 82, 7048–7052 (1985).
Rothbard, J. B. & Taylor, W. R. EMBO J. 7, 93–100 (1988).
Cornette, J. L., Margalit, H., DeLisi, C. & Berzofsky, J. A. Meth. Enzym. 178, 611–633 (1989).
Sette, A. et al. Proc. natn. Acad. Sci. U.S.A. 86, 3296–3300 (1989).
Maryanski, J. L., Verdini, A. S., Weber, P. C., Salemme, F. R. & Corradin, G. Cell 60, 63–72 (1990).
Bastin, J., Rothbard, J., Davey, J., Jones, I. & Townsend, A. J. exp. Med. 165, 1508–1523 (1987).
Bjorkman, P. J. & Davis, M. M. Cold Spring Harb. Symp. quant. Biol. 54, 365–374 (1989).
Bouillot, M. et al. Nature 339, 473–475 (1989).
Frelinger, J. A., Gotch, F. M. Zweerink, H., Wain, E. & McMichael, A. J. J. exp. Med. 172, 827–834 (1990).
Schild, H., Rötzschke, O., Kalbacher, H. & Rammensee, H.-G. Science 247, 1587–1589 (1990).
Townsend, A. et al. Nature 340, 443–448 (1989).
Elliott, T., Townsend, A. & Cerundolo, V. Nature 348, 195–197 (1990).
Cerundolo, V. et al. Nature 345, 449–452 (1990).
Rüsch, E., Kuon, W. & Hämmerling, G. J. Trans. Proc. 15, 2093–2096 (1983).
Lemke, H., Hämmerling, G. J. & Hämmerling, U. Immunol. Rev. 47, 175–206 (1979).
Ozato, K. & Sachs, D. H. J. Immun. 126, 317–321 (1981).
Parham, P. & Brodsky, F. M. Hum. Immun. 3, 277–299 (1981).
Taylor, P. M., Davey, J., Howland, K., Rothbard, J. B. & Askonas, B. A. Immunogenetics 26, 267–272 (1987).
Braciale, T. J. et al. J. exp. Med. 166, 678–692 (1987).
Braciale, T. J., Sweetser, M. T., Morrison, L. A., Kittlesen, D. J. & Braciale, V. L. Proc. natn. Acad. Sci. U.S.A. 86, 277–281 (1989).
Kuwano, K., Braciale, T. J. & Ennis, F. A. FASEB J. 2, 2221 (1988).
Maryanski, J. L., Pala, P., Cerottini, J. C. & Corradin, G. J. exp. Med. 167, 1391–1405 (1988).
Maryanski, J. L., Pala, P., Corradin, G., Jordan, B. R. & Cerottini, J. C. Nature 324, 578–579 (1986).
Sibille, C. et al. J. exp. Med. 172, 35–45 (1990).
Romero, P. et al. Nature 341, 323–326 (1989).
Weiss, W. R. et al. J. exp. Med. 171, 763–773 (1990).
Kast, W. M. et al. Cell 59, 603–614 (1989).
Oldstone, M. B. A., Whitton, J. L., Lewicki, H. & Tishon, A. J. exp. Med. 168, 559–570 (1988).
Tevethia, S. S. et al. J. Virol. 64, 1192–1200 (1990).
Carbone, F. R. & Bevan, M. J. J. exp. Med. 169, 603–612 (1989).
Schumacher, T. N. M. et al. Cell 62, 563–567 (1990).
Walker, B. D. et al. Proc. natn. Acad. Sci. U.S.A. 86, 9514–9518 (1989).
Gotch, F., McMichael, A. & Rothbard, J. J. exp. Med. 168, 2045–2057 (1988).
Santos-Aguado, J., Crimmins, M. A. V., Mentzer, S. J., Burakoff, S. J. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 86, 8936–8940 (1989).
Claverie, J. M. et al. Eur. J. Immun. 18, 1547–1553 (1988).
Falk, K. et al. J. exp. Med. (in the press).
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Falk, K., Rötzschke, O., Stevanovié, S. et al. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290–296 (1991). https://doi.org/10.1038/351290a0
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DOI: https://doi.org/10.1038/351290a0
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