Abstract
Two genes, ldd-3 and ldd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of ldd-3 may reside on human chromosomes 1 or 4 and ldd-4 on chromosome 17.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Metcalfe, M. A. & Baum, J. D. Br. Med. J. 302, 443–447 (1991).
Castano, L. & Eisenbarth, G. S. A. Rev. Immun. 8, 647–679 (1990).
Bottazzo, G. F. et al. Br. Med. Bull. 45, 37–57 (1989).
Olmos, P. et al. Diabetologia 31, 747–750 (1988).
Thomson, G. et al. Am. J. hum. Genet. 43, 799–816 (1988).
Todd, J. A. Immun. Today 11, 122–129 (1990).
Thomson, G., Robinson, W. P., Kuhner, M. K., Joe, S. & Klitz, W. Genet. Epidemiol. 6, 155–160 (1989).
Risch, N. Am. J. hum. Genet. 40, 1–14 (1987).
Makino, S. et al. Expl. Anim. 29, 1–13 (1980).
Serreze, D. V. & Leiter, E. H. J. Immun. 140, 3801–3807 (1988).
Hatamori, N., Yokono, K., Hagata, M., Shii, K. & Baba, S. Diabetes 39, 1070–1078 (1990).
Faustman, D., Eisenbarth, G., Daley, J. & Breitmeyer, J. Diabetes 38, 1462–1468 (1989).
Sibley, R. K., Sutherland, D. E. R., Goetz, F. & Michael, A. F. Lab. Invest. 53, 132–144 (1985).
Hattori, M. et al. Science 231, 733–735 (1986).
Prochazka, M., Leiter, E. H., Serreze, D. V. & Coleman, D. L. Science 237, 286–289 (1987).
Wicker, L. S. et al. J. exp. Med. 165, 1639–1654 (1987).
Livingstone, A., Edwards, C. T., Shizura, J. A. & Fathman, C. G. J. Immun. 146, 529–534 (1991).
Suzuki, T. et al. in Immune-deficient Animals in Biomedical Research (eds Rygaard, J., Groem, N. & Spang-Thomsen, M.), 112–116 (Karger, Basel, 1987).
Oldstone, M. B. A. Science 239, 500–502 (1988).
Wilberz, S., Partke, H. J., Dagnaes-Hansen, F. & Herberg, L. Diabetologia 34, 2–5 (1991).
Miyazaki, T. et al. Nature 345, 722–724 (1990).
Slattery, R. M. et al. Nature 345, 724–726 (1990).
Lund, T. et al. Nature 345, 727–729 (1990).
Wicker, L. S., DeLarato, N. H., Pressey, A. & Peterson, L. B. in Proceedings of the P & S Biomedical Sciences Symposia; Molecular Mechanisms of Immunological Self-Recognition (eds Vogel, H. J. & Alt, S. W.) (Academic, New York, in the press).
Wicker, L. S., DeLarato, N. H., Pressey, A. & Peterson, L. B. in Frontiers in Diabetes Research II: Lessons from Animal Diabetes III (ed. Shafrir, E.) (Smith-Gordon, in the press).
Wicker, L. S., Miller, B. J., Fischer, P. A., Pressey, A. & Peterson, L. B. J. Immun. 142, 781–784 (1989).
White, R. et al. Nature 313, 101–105 (1985).
Paterson, A. H. et al. Genetics 127, 181–197 (1991).
Neumann, P. E. & Collins, R. L. Proc. natn. Acad. Sci. U.S.A. (in the press).
Weber, J. L. & May, P. E. Am. J. hum. Genet. 44, 388–396 (1989).
Litt, M. & Luty, J. A. Am. J. hum. Genet. 44, 397–401 (1989).
Tautz, D. Nucleic Acids Res. 17, 6463–6471 (1989).
Love, J. M., Knight, A. M., McAleer, M. A. & Todd, J. A. Nucleic Acids Res. 18, 4123–4130 (1990).
Aitman, T. J., Hearne, C. M., McAleer, M. A. & Todd, J. A. Mammalian Genome (in the press).
Hearne, C. M. et al. Mammalian Genome (in the press).
Cornall, R. J., Aitman, T. J., Hearne, C. M. & Todd, J. A. Genomics (in the press).
Knight, A. M. & Dyson, P. J. Molec Cell. Probes 4, 497–504 (1990).
Hillyard, A. L., Doolittle, D. P., Davisson, M. T. & Roderick, T. H. Locus Map of the Mouse with Comparative Points of Human on Mouse (The Jackson Laboratory, Bar Harbor, Maine, 1990).
Ott, J. in Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, London, 1985).
Acha-Orbea, H. et al. Nature 350, 207–211 (1991).
Janssen, L. A. J. et al. Genomics 8, 237–242 (1990).
Carter, T. C. & Falconer, D. S. J. Genet. 50, 307–323 (1951).
Philbrick, W. M., Maher, S. E., Bridgett, M. M. & Bothwell, A. L. M. EMBO J. 9, 2485–2492 (1990).
Herold, K. C., Montag, A. G., Meyer, S. M., Wojcikowski, C. & Fitch, F. W. Diabetes 39, 815–820 (1990).
Nadeau, J. H. Trends Genet. 5, 82–86 (1989).
Lathrop, G. M. et al. Genomics 2, 157–164 (1988).
Parnes, J. R. & Seidman, J. G. Cell 29, 661–669 (1982).
Marth, J. D., Peet, R., Krebs, E. G. & Perlmutter, R. M. Cell 43, 393–404 (1985).
Rice, J. & Risch, N. Genet. Epidemiol. 6, 161–177 (1989).
Lathrop, G. M., Lalouel, J., Julier, C. & Ott, J. Am. J. hum. Genet. 37, 482–498 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Todd, J., Aitman, T., Cornall, R. et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351, 542–547 (1991). https://doi.org/10.1038/351542a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/351542a0
This article is cited by
-
Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14
Diabetologia (2010)
-
Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects
Immunogenetics (2010)
-
Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region
Immunogenetics (2006)
-
Strategies for mapping and cloning quantitative trait genes in rodents
Nature Reviews Genetics (2005)
-
MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury
Laboratory Investigation (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.