Abstract
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.
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Carmeliet, P., Schoonjans, L., Kieckens, L. et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368, 419–424 (1994). https://doi.org/10.1038/368419a0
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DOI: https://doi.org/10.1038/368419a0
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