Abstract
IMMUNE defence against pathogens entering the gut is accomplished by lymphocytes in the gut-associated lymphoid tissue (GALT), a major compartment of the immune system1. The GALT, comprising Peyer's patches, lamina propria lymphocytes and intra-epithelial lymphocytes of the intestine, is populated by lymphocytes that migrate there from the vasculature2,3. Here we report that, in mice deficient for the β7 integrin subfamily of adhesion molecules, the formation of the GALT is severely impaired. This is probably due to a failure of β7–/– lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the GALT.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Brandtzaeg, P. Curr. Topics Microbiol. Immun. 146, 13–25 (1989).
Butcher, E. C. & Picker, L. J. Science 272, 60–66 (1996).
Imhof, B. A. & Dunon, D. Adv. Immun. 58, 345–416 (1995).
Carlos, T. M. & Harlan, J. M. Blood 84, 2068–2101 (1994).
Butcher, E. C. Cell 67, 1033–1036 (1991).
Springer, T. A. Cell 76, 301–314 (1994).
Holzmann, B., Mclntyre, B. W. & Weissman, I. L. Cell 56, 37–46 (1989).
Holzmann, B. & Weissman, I. L. EMBO J. 8, 1735–1741 (1989).
Cerf-Bensussan, N., Begue, B., Gagnon, J. & Meo, T. Eur. J. Immun. 22, 273–277 (1992).
Parker, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 89, 1924–1928 (1992).
Hamann, A., Andrew, D. P., Jablonski-Westrich, D., Holzmann, B. & Butcher, E. C. J. Immun. 152, 3282–3293 (1994).
Bargatze, R. F., Jutila, M. A. & Butcher, E. C. Immunity 3, 99–108 (1995).
Cepek, K. L. et al. Nature 372, 190–193 (1994).
Podolsky, D. K. et al. J. clin. Invest. 92, 372–380 (1993).
Rocha, B., Vassalli, P. & Guy-Grand, D. J. exp. Med. 180, 681 (1994).
Butcher, E., Scollay, R. & Weissman, I. J. Immun. 123, 1996–2003 (1979).
Arbones, M. L. et al. Immunity 1, 247–260 (1994).
Sundberg, J. P., Elson, C. O., Bedigian, H. & Birkenmeier, E. H. Gastroenterology 107, 1726–1735 (1994).
Kilshaw, P. J. & Murant, S. J. Eur. J. Immun. 21, 2591–2597 (1991).
Griebel, P. J. & Hein, W. R. Immun. Today 17, 30–39 (1996).
Guy-Grand, D. et al. Eur. J. Immun. 22, 505–510 (1992).
Sim, G. K., Rajaserkar, R., Dessing, M. & Augustin, A. In. Immun. 6, 1287–1295 (1994).
Hirsch, E., Iglesias, A., Potocnik, A. J., Hartmann, U. & Fässler, R. Nature 380, 171–175 (1996).
Arroyo, A. G., Yang, J. T., Rayburn, H. & Hynes, R. O. Cell 85, 997–1008 (1996).
Kühn, R., Rajewsky, K. & Müller, W. Science 254, 707–710 (1991).
Zou, Y. R., Takeda, S. & Rajewsky, K. EMBO J. 12, 811–820 (1993).
Andrew, D. et al. J. Immun. 153, 3847 (1994).
Hsu, S., Raine, L. & Fanger, H. J. Histochem. Cytochem. 29, 577–580 (1981).
Kunkel, E. J. et al. J. exp. Med. 183, 57–65 (1996).
Gallatin, W. M., Weissman, I. L. & Butcher, E. C. Nature 304, 30–34 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wagner, N., Löhler, J., Kunkel, E. et al. Critical role for β7 integrins in formation of the gut-associated lymphoid tissue. Nature 382, 366–370 (1996). https://doi.org/10.1038/382366a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/382366a0
This article is cited by
-
Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs
BMC Genomics (2023)
-
Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis
Mucosal Immunology (2022)
-
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses
Mucosal Immunology (2022)
-
The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors
Nature Immunology (2022)
-
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium
Mucosal Immunology (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.