Abstract
THE B cells within the germinal centres of lymphoid organs undergo affinity maturation of their antigen receptors, a critical event for antibody memory1–3. Follicular dendritic cells within the germinal centres retain immune complexes4–6 that select the developing B cells for which they have a higher affinity7. We have now identified a subset of CD4+CD11c+CD3− dendritic cells in the germinal centres. These are strong antigen-presenting cells for T cells, but do not co-stimulate CD40-activated B cells. These dendritic cells probably stimulate germinal centre T cells and aid the complicated processes that are required for the generation of memory B cells.
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Grouard, G., Durand, I., Filgueira, L. et al. Dendritic cells capable of stimulating T cells in germinal centres. Nature 384, 364–367 (1996). https://doi.org/10.1038/384364a0
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DOI: https://doi.org/10.1038/384364a0
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