Abstract
We evaluated the effect of a chronic treatment with Tadalafil on progenitor cells (PCs) number and endothelial function in patients with erectile dysfunction (ED) with or without cardiovascular risk factors. Twenty-six subjects with ED and 23 aged matched controls were studied. All subjects underwent blood tests, International Index of Erectile Function (IIEF-5), Nocturnal Penile Tumescence Rigidity Monitoring test (NPTRM), brachial artery flow-mediated dilation (FMD) and PCs count. International index of erectile function, FMD and PC count were re-evaluated in all subjects at the end of Tadalafil and placebo treatment. With respect to controls patients had lower basal FMD (P<0.05) and basal PCs (P<0.05). Treatment with Tadalafil determined a significant increase in PCs (P<0.001) and FMD (P<0.001) with respect to basal level. Positive correlation was found between basal FMD and PCs (P<0.05) and between basal FMD and PCs increase after Tadalafil treatment (P<0.05). Tadalafil promotes a mobilization of PCs and improves endothelial function in ED patients.
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References
Verma S, Buchanan MR, Anderson TJ . Endothelial function as a biomarker of vascular disease. Circulation 2003; 108: 2054–2059.
Verma S, Anderson TJ . Fundamentals of endothelial function for the clinical cardiologist. Circulation 2002; 105: 546–549.
Solomon H, Man JW, Jackson G . Erectile dysfunction and the cardiovascular patients: endothelial dysfunction is the common denominator. Heart 2003; 89: 251–253.
Kirby M, Jackson G, Simonsen U . Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 2005; 59: 225–229.
Fung MM, Bettencourt R, Barrett-Connor E . Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. J Am Coll Cardiol 2004; 43: 1405–1411.
Yavuzgil O, Altay B, Zoghi M, Gurgun C, Kayikcioglu M, Kultursay H . Endothelial function in patients with vasculogenic erectile dysfunction. Int J Cardiol 2005; 103: 19–26.
Caretta N, Palego P, Ferlin A, Garolla A, Bettella A, Selice R et al. Resumption of spontaneous erections in selected patients affected by erectile dysfunction and various degrees of carotid wall alteration: role of Tadalafil. Eur Urol 2005; 48: 326–331.
Asahara T, Murohara T, Sullivan A, Silver M, Zee R, Li T et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964–967.
Dimmeler S, Zeiher AM . Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 2004; 82: 671–677.
Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353: 999–1007.
Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370–1376.
Foresta C, Lana A, Cabrelle A, Ferigo M, Caretta N, Garolla A et al. PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans. Int J Impot Res 2005; 17: 377–380.
Munoz M, Bancroft J, Marshall I . The performance of the RigiScan in the measurement of penile tumescence and rigidity. Int J Impot Res 1993; 5: 69–76.
Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257–265.
Scheubel RJ, Silber RE, Kuss O, Morawietz H, Holtz J, Simm A . Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 2003; 42: 2073–2080.
Handgretinger R, Gordon PR, Leimig T, Chen X, Buhring HJ, Niethammer D et al. Biology and plasticity of CD133+ hematopoietic stem cells. Ann NY Acad Sci 2003; 996: 141–151.
Stacey P, Rulten S, Dapling A, Phillips SC . Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem Biophys Res Commun 1998; 247 (2): 249–254.
Shim HJ, Kim YC, Jang JM, Park KJ, Kim DH, Kang KK et al. Subacute toxicities and toxicokinetics of DA-8159, a new phosphodiesterase type V inhibitor, after single and 4-week repeated oral administration in rats. Biopharm Drug Dispos 2003; 24: 409–418.
Choi SM, Kim JE, Kang KK . Chronic treatment of DA-8159, a new phosphodiesterase type 5 inhibitor, attenuates endothelial dysfunction in stroke-prone spontaneously hypertensive rat. Life Sci 2005 [E-pub ahead of print].
Foresta C, Caretta N, Lana A, Cabrelle A, Palu G, Ferlin A . Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res 2005; 17: 288–290.
Schmidt-Luckec C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kanmper U et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005; 111: 2981–2987.
Deanfield J, Donald A, Ferri C, Giannattasio C, Halcox J, Halligan S et al. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005; 23: 7–17.
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Foresta, C., Ferlin, A., De Toni, L. et al. Circulating endothelial progenitor cells and endothelial function after chronic Tadalafil treatment in subjects with erectile dysfunction. Int J Impot Res 18, 484–488 (2006). https://doi.org/10.1038/sj.ijir.3901465
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DOI: https://doi.org/10.1038/sj.ijir.3901465
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