Abstract
We investigated the effect of early sildenafil dose optimization and personalized instructions on sexual intercourse success in 1109 men beginning sildenafil therapy for erectile dysfunction. In phase 1 (4 weeks), patients followed the instructions contained in the sildenafil (50 mg) sample pack and had 1.4 sexual intercourse attempts per week with 82% success. Patients (17%) had a second intercourse attempt (80% successful): 58% occurred within 4 h, 20% within 5–8 h, and 22% within 9–24 h of the first attempt. In phase 2 (4 weeks), sildenafil was adjusted as needed (53% to 100 mg, and 2% to 25 mg), and investigators provided personalized instructions to facilitate patient success. Sexual intercourse attempts increased to 1.7 per week, with 91% success, and 18% were followed by a second attempt, of which 91% were successful. Most patients requested the 100-mg dose, which helped improve sexual intercourse frequency, flexibility and success.
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Acknowledgements
This study was funded by Pfizer Inc. Editorial support was provided by Carl Clay, PhD, at Complete Healthcare Communications Inc., and was funded by Pfizer Inc. The authors thank all investigators who contributed to this study: Abraham Morgentaler, MD, Brookline, MA; Robert Lesser, MD, New Orleans, LA; Barton Wachs, MD, Long Beach, CA; Robert Lipetz, MD, San Diego, CA; William Borkon, MD, Minneapolis, MN; Glen Wells, MD, Birmingham, AL; David Mobley, MD, Houston, TX; Donald Kidd, MD, Mobile, AL; Gilbert Dale, MD, Fresno, CA; David Kaufman, MD, New York, NY; Stephen Auerbach, MD, Newport Beach, CA; Marcia Miller, MD, Gainesville, FL; Gordon Brody, MD, Arlington, TX; Gary Oshinksy, MD, Garden City, NY; Han Hanafy, MD, Harrisburg, IL; Emerson Harrison, MD, Decatur, GA; Robert Modarelli, MD, Tacoma, WA; Irving Fishman, MD, Houston, TX; Simon Mirelman, MD, Birmingham, AL; Irvin Hirsch, MD, Philadelphia, PA; Adrian James, MD, New Orleans, LA; James Bailen, MD, Jeffersonville, IN; John Cudecki, MD, Chicago, IL; James McMurray, MD, Huntsville, AL; John Mulhall, MD, New York, NY; Vahan Kassabian, MD, Atlanta, GA; Mark Swierzewski, MD, Tampa, FL; Gary Karlin, MD, Lawrenceville, NJ; Lynn Conrad, MD, Germantown, TN; Albert Canas, MD, Miami Beach, FL; Charles White, MD, Mobile, AL; Martin Dineen, MD, Daytona Beach, FL; Michael O'Leary, MD, Boston, MA; Neil Baum, MD, New Orleans, LA; Brian Roberts, MD, Myrtle Beach, SC; Joseph Banno, MD, Peoria, IL; William Fitch, MD, San Antonio, TX; Robert Gessler, MD, Laurel, MD; Michael Collins, MD, Hoover, AL; Ronald Castellanos, MD, Fort Myers, FL; Rafael Wurzel, MD, New Britain, CT; Robert Salant, MD, New York, NY; Samuel Axelrad, MD, Houston, TX; Stanley Brosman, MD, Marina Del Rey, CA; Fernando Borges, MD, St. Petersburg, FL; Robert Waldbaum, MD, Manhassett, NY; Laurence, Belkoff, DO, Bala Cynwyd, PA; William Jennings, MD, San Antonio, TX; William Monnig, MD, Cincinnati, OH; Walter Pittman, MD, Homewood, AL; Connie Abarikwu, MD, Phoenix, AZ; James Barada, MD, Albany, NY; Winston Barzell, MD, Sarasota, FL; Martin, Bastuba, MD, La Mesa, CA; Teresa, Beam, MD; Indianapolis, IN; Robert Brannigan, MD, Chicago, IL; Joseph Camps, MD, Tallahassee, FL; Stacy Childs, MD, Cheyenne, WY; James Cochran, MD, Dallas, TX; Ronald DeGuerre, MD, St. Louis, MO; Jules Deutsch, MD, Gretna, LA; Craig Donatucci, MD, Durham, NC; Robert Eastridge, MD, Palm Beach Gardens, FL; Robert Feldman, MD, Waterbury, CT; Floyd Freiden, MD, Kansas City, MO; Rene Frontera, MD, St. Clair Shores, MI; Louis Galdieri, MD, West Orange, NJ; Phillip Ginsberg, DO, Philadelphia, PA; Marc Gittelman, MD, Aventura, FL; William Glover, MD, Fairfax, VA; Kenneth Goldberg, Carrollton, TX; Abraham Hawatmeh, MD, St. Louis, MO; Wayne Hellstrom, MD, New Orleans, LA; Stanton Honig, MD, New Haven, CT; David Jablonski, MD, Orlando, FL; Joel Kaufman, MD, Aurora, CO; Ira Klimberg, MD, Ocala, FL; Dean Knoll, MD, Nashville, TN; Michael Lutz, MD, Southfield, MI; Myron Murdock, MD, Greenbelt, MD; Gregory Parr, MD, Port Orange, FL; Arthur Pinto, MD, Trumbull, CT; Steven Promisloff, MD, Hillsboro, OR; Stephen Sacks, MD, Los Angeles, CA; William Scaljon, MD, Atlanta, GA; Robert Sher, MD, Rockville, MD; Ned Stein, MD, Houston, TX; David Talley, MD, San Antonio, TX; William Terens, MD, Edison, NJ; Kevin Tomera, MD, Anchorage, AK; Frank Tortora, MD, Cary, NC; John Tuttle, MD, Lexington, KY; Larry Walker, MD, Memphis, TN; Douglas Ward, MD, Washington, DC; Michael Werner, MD, Purchase, NY; Kenneth Wiley, MD, New Orleans, LA.
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Steidle, C., McCullough, A., Kaminetsky, J. et al. Early sildenafil dose optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction. Int J Impot Res 19, 154–160 (2007). https://doi.org/10.1038/sj.ijir.3901498
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DOI: https://doi.org/10.1038/sj.ijir.3901498
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