A study of the thermodynamics of antibody binding to a crucial HIV protein has shed light on why the virus so effectively evades the antibody arm of the immune response. Changes in the protein's conformation are the key.
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Jardetzky, T. Conformational camouflage. Nature 420, 623–624 (2002). https://doi.org/10.1038/420623a
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DOI: https://doi.org/10.1038/420623a