The p53 protein is notorious for its involvement in many cancers. Studies in mice are helping to clarify how mutations in the human p53 protein produce a wide variety of tumours.
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Dyke, T. Sense out of missense. Nature 434, 287–288 (2005). https://doi.org/10.1038/434287a
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DOI: https://doi.org/10.1038/434287a