Restricting dietary intake is one way to promote longevity. The identification of two genes that specifically mediate this effect in worms provides insight into the molecular mechanisms underlying ageing.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
Molecular Neurodegeneration Open Access 27 April 2016
-
A metabolic signature of long life in Caenorhabditis elegans
BMC Biology Open Access 10 February 2010
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J. & Dillin, A. Nature 447, 550–555 (2007).
Bishop, N. A. & Guarente, L. Nature 447, 545–549 (2007).
Horner, M. A. et al. Genes Dev. 12, 1947–1952 (1998).
Kalb, J. M. et al. Development 125, 2171–2180 (1998).
Friedman, J. R. & Kaestner, K. H. Cell. Mol. Life Sci. 63, 2317–2328 (2006).
Kenyon, C. Cell 120, 449–460 (2005).
Wolff, S. et al. Cell 124, 1039–1053 (2006).
Zhang, L., Rubins, N. E., Ahima, R. S., Greenbaum, L. E. & Kaestner, K. H. Cell Metab. 2, 141–148 (2005).
Bowerman, B., Eaton, B. A. & Priess, J. R. Cell 68, 1061–1075 (1992).
An, J. H. & Blackwell, T. K. Genes Dev. 17, 1882–1893 (2003).
Zhang, D. D. Drug Metab. Rev. 38, 769–789 (2006).
Bargmann, C. I. & Horvitz, H. R. Neuron 7, 729–742 (1991).
Li, C. Parasitology 131 (Suppl.), S109–S127 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Antebi, A. When less is more. Nature 447, 536–537 (2007). https://doi.org/10.1038/447536a
Published:
Issue Date:
DOI: https://doi.org/10.1038/447536a
This article is cited by
-
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
Molecular Neurodegeneration (2016)
-
Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans
Archives of Pharmacal Research (2014)
-
A metabolic signature of long life in Caenorhabditis elegans
BMC Biology (2010)