Abstract
Luteinising hormone releasing hormone (LHRH) analogues are routinely used in the treatment of patients with advanced prostate cancer. This randomised crossover trial was conducted to compare patient comfort and tolerability between two commonly used LHRH analogues: goserelin acetate and leuprorelin acetate.
A total of 50 patients were randomised into two groups, each receiving 6-monthly injections of leuprorelin acetate (a liquid presentation) and goserelin acetate (a depot pellet) and crossing over between treatments. Patients completed a simple visual analogue score for the discomfort felt from the injections. An analysis of variance model was used, and the results found that patients do tolerate leuprorelin acetate (0.589) better than goserelin acetate (1.343) (P<0.001, CI=95%).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 4 print issues and online access
$259.00 per year
only $64.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pienta KJ . Etiology epidemiology, and prevention of carcinoma of the prostate. In: Walsh PC, Retik AB, Darracott Vaughan E, Wein AJ, (eds). Campbell's Urology, (7th edn.) WB Saunders Company, Philadelphia, pp 2489–2496. (1998)
The RCR COIN/BAUS Prostate Cancer Working Group. Guidelines on the management of prostate cancer. BJU Int 84: 987–1014. (1999)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Williams, G., Lindsay, S. & Bowsher, W. Randomised crossover trial to assess the tolerability of LHRH analogue administration. Prostate Cancer Prostatic Dis 6, 187–189 (2003). https://doi.org/10.1038/sj.pcan.4500625
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.pcan.4500625
Keywords
This article is cited by
-
Effectiveness of skin icing in reducing pain associated with goserelin acetate injection
International Journal of Clinical Oncology (2010)
-
Does needle size matter? Patient experience of luteinising hormone-releasing hormone analogue injection
Prostate Cancer and Prostatic Diseases (2005)