Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

TGFBR1*6A is not associated with prostate cancer in men of European ancestry

Prostate Cancer and Prostatic Diseases volume 8, pages 50–53 (2005)Cite this article

Abstract

The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case–control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the *6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jemal A et al. Cancer statistics, 2003. CA Cancer J Clin 2003; 53: 5–26.

    Article  Google Scholar 

  2. Lichtenstein P et al. Environmental and heritable factors in the causation of cancer — Analyses of cohorts of twins from Sweden, Denmark, and Finland. N Eng J Med 2000; 343: 78–85.

    Article  CAS  Google Scholar 

  3. Markowitz S et al. Inactivation of type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 1995; 268: 1336–1338.

    Article  CAS  Google Scholar 

  4. Kim IY et al. Genetic change in transforming growth factor β (TGF-β) receptor type I gene correlates with insensitivity to TGF-β 1 in human prostate cancer cells. Cancer Res 1996; 56: 44–48.

    CAS  PubMed  Google Scholar 

  5. DeCoteau JF et al. Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1997; 94: 5877–5881.

    Article  CAS  Google Scholar 

  6. Chen T, Carter D, Garrigue-Antar L, Reiss M . Transforming growth factor β type 1 receptor kinase mutant associated with metastatic breast cancer. Cancer Res 1998; 58: 4805–4810.

    CAS  PubMed  Google Scholar 

  7. Ohwada M et al. Mutational analysis of transforming growth factor β receptor type II and DNA mismatch repair genes in sporadic endometrial carcinomas with microsatellite instability. Oncol Rep 2000; 7: 789–792.

    CAS  PubMed  Google Scholar 

  8. Wang D et al. Analysis of specific gene mutations in the transforming growth factor-β signal transduction pathway in human ovarian cancer. Cancer Res 2000; 60: 4507–4512.

    CAS  Google Scholar 

  9. Baxter SW, Choong DYH, Eccles DM, Campbell IG . Transforming growth factor β receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer. Cancer Epidemiol Biomarkers Prevention 2002; 11: 211–214.

    CAS  Google Scholar 

  10. Pasche B et al. Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res 1998; 58: 2727–2732.

    CAS  PubMed  Google Scholar 

  11. Pasche B et al. T beta R-I(6A) is a candidate tumor susceptibility allele. Cancer Res 1999; 59: 5678–5682.

    CAS  PubMed  Google Scholar 

  12. Samowitz WS, Curtin K, Leppert MF, Slattery ML . Uncommon TGFBRI allele is not associated with increased susceptibility to colon cancer. Genes Chromosome Cancer 2001; 32: 381–383.

    Article  CAS  Google Scholar 

  13. Kaklamani VG et al. TGFBR1*6A and cancer risk: a meta-analysis of seven case-control studies. J Clin Oncol 2003; 21: 3236–3243.

    Article  CAS  Google Scholar 

  14. Pasche B et al. TGFBR1*6A and cancer: a meta-analysis of 12 case-control studies. J Clin Oncol 2004; 22: 756–758.

    Article  Google Scholar 

  15. Smith DS, Humphrey PA, Catalona WJ . The early detection of prostate carcinoma with prostate specific antigen — The Washington University Experience. Cancer 1997; 80: 1852–1856.

    Article  CAS  Google Scholar 

  16. Lange K, Weeks D, Boehnke M . Programs for pedigree analysis: MENDEL, FISHER and dGENE. Genet Epidemiol 1988; 5: 471–472.

    Article  CAS  Google Scholar 

  17. Boehnke M . Allele frequency estimation from data on relatives. Am J Hum Genet 1991; 48: 22–25.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Chen T et al. Structural alterations of transforming growth factor-beta receptor genes in human cervical carcinoma. Int J Cancer 1999; 82: 43–51.

    Article  CAS  Google Scholar 

  19. Van Tilborg AA, de Vries A, Zwarthoff EC . The chromosome 9q genes TGFBR1, TSC1, and ZNF189 are rarely mutated in bladder cancer. J Pathol 2001; 194: 76–80.

    Article  CAS  Google Scholar 

  20. Wikström P, Bergh A, Damber J-E . Transforming growth factor-β1 and prostate cancer. Scan J Urol Nephrol 2000; 34: 85–94.

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by an award from the Urological Research Foundation, St Louis.

Author information

Authors and Affiliations

  1. Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA

    B K Suarez & C H Jin

  2. Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA

    B K Suarez

  3. Center for Genome Information, Department of Environmental Health, Cancer Genetics Program, University of Cincinnati, Cincinnati, Ohio, USA

    P Pal, R Kaushal, G Sun, L Jin & R Deka

  4. Division of Hematology and Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

    B Pasche

  5. Department of Urology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

    W J Catalona

Authors
  1. B K Suarez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P Pal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C H Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R Kaushal
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B Pasche
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R Deka
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. W J Catalona
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B K Suarez.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Suarez, B., Pal, P., Jin, C. et al. TGFBR1*6A is not associated with prostate cancer in men of European ancestry. Prostate Cancer Prostatic Dis 8, 50–53 (2005). https://doi.org/10.1038/sj.pcan.4500765

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.pcan.4500765

Keywords

This article is cited by

Search

Advanced search

Quick links