Five studies show that disabling p53, an essential tumour-suppressor protein, improves the efficiency of stem-cell production. Are these results a 'heads up' that cancer cells and stem cells are disturbingly similar?
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells
Signal Transduction and Targeted Therapy Open Access 31 March 2021
-
MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade
Scientific Reports Open Access 17 February 2021
-
Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
Journal of Experimental & Clinical Cancer Research Open Access 03 June 2020
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hong, H. et al. Nature 460, 1132–1135 (2009).
Li, H. et al. Nature 460, 1136–1139 (2009).
Kawamura, T. et al. Nature 460, 1140–1144 (2009).
Utikal, J. et al. Nature 460, 1145–1148 (2009).
Marión, R. M. et al. Nature 460, 1149–1153 (2009).
Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).
Nakagawa, M. et al. Nature Biotechnol. 26, 101–106 (2008).
Okita, K. et al. Science 322, 949–953 (2008).
Zhou, H. et al. Cell Stem Cell 4, 381–384 (2009).
Banito, A. et al. Genes Dev. (in the press).
Livingstone, L. R. et al. Cell 70, 923–935 (1992).
Eliyahu, D., Raz, A., Gruss, P., Givol, D. & Oren, M. Nature 312, 646–649 (1984).
Krizhanovsky, V. et al. Cold Spring Harb. Symp. Quant. Biol. 73, 513–522 (2008).
Lin, T. et al. Nature Cell Biol. 7, 165–171 (2005).
Mali, P. et al. Stem Cells 26, 1998–2005 (2008).
Zhao, Y. et al. Cell Stem Cell 3, 475–479 (2008).
Lowe, S. W. et al. Science 266, 807–810 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krizhanovsky, V., Lowe, S. The promises and perils of p53. Nature 460, 1085–1086 (2009). https://doi.org/10.1038/4601085a
Published:
Issue Date:
DOI: https://doi.org/10.1038/4601085a
This article is cited by
-
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells
Signal Transduction and Targeted Therapy (2021)
-
MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade
Scientific Reports (2021)
-
Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
Journal of Experimental & Clinical Cancer Research (2020)
-
Senescence-associated reprogramming promotes cancer stemness
Nature (2018)
-
SIRT2 is required for efficient reprogramming of mouse embryonic fibroblasts toward pluripotency
Cell Death & Disease (2018)