The small molecule rapamycin, already approved for clinical use for various human disorders, has been found to significantly increase lifespan in mice. Is this a step towards an anti-ageing drug for people?
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The mTOR pathway is necessary for survival of mice with short telomeres
Nature Communications Open Access 03 March 2020
-
Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
Biogerontology Open Access 09 August 2017
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Harrison, D. E. et al. Nature 460, 392–395 (2009).
Jia, K., Chen, D. & Riddle, D. L. Development 131, 3897–3906 (2004).
Kaeberlein, M. et al. Science 310, 1193–1196 (2005).
Kapahi, P. et al. Curr. Biol. 14, 885–890 (2004).
Powers, R. W. 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K. & Fields, S. Genes Dev. 20, 174–184 (2006).
Vellai, T. et al. Nature 426, 620 (2003).
Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. & Kennedy, B. K. Biochim. Biophys. Acta advance online publication doi:10.1016/j.bbagen.2009.06.007 (2009).
Smith, E. D. et al. Genome Res. 18, 564–570 (2008).
Steffen, K. K. et al. Cell 133, 292–302 (2008).
Hansen, M. et al. PLoS Genet. 4, e24 (2008).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
M.K. and B.K.K. have patents pending for high-throughput methods for measuring lifespan in yeast.
Rights and permissions
About this article
Cite this article
Kaeberlein, M., Kennedy, B. A midlife longevity drug?. Nature 460, 331–332 (2009). https://doi.org/10.1038/460331a
Published:
Issue Date:
DOI: https://doi.org/10.1038/460331a
This article is cited by
-
The mTOR pathway is necessary for survival of mice with short telomeres
Nature Communications (2020)
-
Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
Biogerontology (2017)
-
NIA’s intervention testing program at 10 years of age
AGE (2015)
-
Listening to public concerns about human life extension
EMBO reports (2010)
-
Genetic, epigenetic and posttranslational mechanisms of aging
Biogerontology (2010)