Short residence times in the bloodstream reduce the effectiveness of protein drugs. Application of an approach that combines protein and polymer engineering prolongs circulation time and increases drug uptake by tumours.
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References
Leader, B., Baca, Q. J. & Golan, D. E. Nature Rev. Drug Discov. 7, 21–39 (2008).
Gao, W., Liu, W., Christensen, T., Zalutsky, M. R. & Chilkoti, A. Proc. Natl Acad. Sci. USA 107, 16432–16437 (2010).
Abuchowski, A., McCoy, J. R., Palczuk, N. C., van Es, T. & Davis, F. F. J. Biol. Chem. 252, 3582–3586 (1977).
Duncan, R. Nature Rev. Drug Discov. 2, 347–360 (2003).
Duncan, R. Nature Rev. Cancer 6, 688–701 (2006).
Veronese, F. M. & Pasut, G. Drug Discov. Today 10, 1451–1458 (2005).
Bailon, P. et al. Bioconj. Chem. 12, 195–202 (2001).
Gao, W. et al. Proc. Natl Acad. Sci. USA 106, 15231–15236 (2009).
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Hubbell, J. Longer-lived proteins. Nature 467, 1051–1052 (2010). https://doi.org/10.1038/4671051a
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DOI: https://doi.org/10.1038/4671051a