The gene CYLD is so named because one of its mutant forms is associated with cylindromatosis, which causes skin tumours.
The CYLD protein is an enzyme; its active site in humans contains a cysteine residue at position 601 (denoted as C in the one-letter amino-acid code). The amino-acid sequence following this cysteine (C) is tyrosine (Y), leucine (L) and aspartate (D). What are the odds of that?
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Boone, D. A protein that spells trouble. Nature 508, 186 (2014). https://doi.org/10.1038/508186e
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DOI: https://doi.org/10.1038/508186e