The growth factor MIDKINE, which is secreted by skin tumours called melanomas, stimulates the formation of lymphatic vessels at distant lymph nodes and organ sites, paving the way for metastatic cancer spread. See Letter p.676
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
Journal of Hematology & Oncology Open Access 08 December 2022
-
Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis
Cell Death Discovery Open Access 11 August 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Faries, M. B. et al. New Engl. J. Med. 376, 2211–2222 (2017).
Olmeda, D. et al. Nature 546, 676–680 (2017).
Petrova, T. V. et al. Cancer Cell 13, 554–556 (2008).
Kaplan, R. N. et al. Nature 438, 820–827 (2005).
Hoshino, A. et al. Nature 527, 329–335 (2015).
Hirakawa, S. et al. Blood 109, 1010–1017 (2007).
Peinado, H. et al. Nature Rev. Cancer 17, 302–317 (2017).
Das, S. et al. Cancer Res. 70, 1814–1824 (2010).
Muramatsu, T. & Kadomatsu, K. Br. J. Pharmacol. 171, 811–813 (2014).
Nolan, D. J. et al. Dev. Cell 26, 204–219 (2013).
Rasmussen, J. C. et al. J. Vasc. Surg. Cases 1, 201–204 (2015).
Rasmussen, J. C., Fife, C. E. & Sevick-Muraca, E. M. Lymphat. Res. Biol. 13, 195–201 (2015).
Author information
Authors and Affiliations
Corresponding authors
Related links
Related links
Related links in Nature Research
Developmental biology: Diversity in the lymphatic vasculature
Rights and permissions
About this article
Cite this article
Hoshino, A., Lyden, D. Lymphatic detours for cancer. Nature 546, 609–610 (2017). https://doi.org/10.1038/546609a
Published:
Issue Date:
DOI: https://doi.org/10.1038/546609a
This article is cited by
-
Ferroptosis is an effective strategy for cancer therapy
Medical Oncology (2024)
-
Ferritinophagy induced ferroptosis in the management of cancer
Cellular Oncology (2024)
-
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
Journal of Hematology & Oncology (2022)
-
Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis
Cell Death Discovery (2021)
-
Peptide P11 suppresses the growth of human thyroid carcinoma by inhibiting the PI3K/AKT/mTOR signaling pathway
Molecular Biology Reports (2019)