Abstract
Purpose
To describe the ocular findings in subjects with congenital heart disease (CHD).
Methods
In a prospective study, the same observer examined 240 consecutive patients with CHD admitted to the medical centre. Two independent geneticists performed identification of syndromes.
Results
The commonest anatomic cardiac anomalies were ventricular or atrial septal defects (62), tetralogy of Fallot (39), pulmonary stenosis (25), and transposition of the great arteries (24). The heart lesions were divided physiologically into volume overload (90), cyanotic (87), and obstructive (63). In all, 105 syndromic subjects included the velocardiofacial syndrome (18), Down's syndrome (17), CHARGE association (6), DiGeorge syndrome (5), Williams syndrome (3), Edwards syndrome (3), Noonan syndrome (3), VACTERL association (2), and Patau syndrome (trisomy 13) (2). The paediatric team recognized 51 patients as syndromic. Two independent geneticists recognized additional 54 patients as syndromic. Positive eye findings were present in 55% (132) and included retinal vascular tortuosity (46), optic disc hypoplasia (30), trichomegaly (15), congenital ptosis (12), strabismus (11), retinal haemorrhages (8), prominent eyes (7), and congenital cataract (6). There was a strong correlation between the retinal vascular tortuosity and both a low haematocrit (P=0.000) and a low arterial oxygen saturation (P=0.002).
Conclusions
Patients with CHD are at a high risk for ocular pathology and need screening for various ocular abnormalities.
Similar content being viewed by others
Introduction
Congenital heart disease (CHD) is one of the most common birth defects, affecting around 1% of live births.1, 2 Both environmental factors and genetic factors have been implicated.1, 2 Ocular studies in CHD are few and have concentrated on one cardiac anomaly,3, 4, 5, 6, 7, 8 one syndrome with cardiac anomaly,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 small series, single case reports,26, 27, 28 or literature review.29 Ocular findings in CHD were not revisited for the past 25 years. In 1967,3 1968,4 and 1972,5 three papers detailed, respectively, the ocular findings in 12, 85, and 83 patients with CHD. A prospective study of the ocular findings in a large series of CHD was undertaken to further define the ocular findings.
Materials and methods
In a prospective study, consecutive patients with CHD admitted to the medical centre were examined between December 1997 and July 2002. The diagnosis of CHD was established by echocardiography or cardiac catheterization by one of the researchers (FB). The Institutional Review Board approved the study protocol, and parents signed a consent form as part of the enrollment in the paediatric cardiology registry.
One observer (AMM) carried the eye examination. This included cycloplegic refraction (four instillations at 15 min interval of tropicamide 1%),30 indirect ophthalmoscopy, and assessment of ptosis. Identification of associated syndromes was based on review of the clinical findings, karyotyping results (done in 27 patients), and review of external photographs of the face, and of accompanying systemic anomalies. Two independent geneticists (EIT, AM) characterized the associated syndromes.
The cardiac lesions were divided physiologically into three categories: volume overload, cyanotic, and obstructive. The category of volume overload included various defects producing left-to-right shunts, resulting in right-sided dilatation (atrial septal defect) or left sided-dilatation (ventricular septal defect, patent ductus arteriosus). The cyanotic category included lesions with right-to-left shunts or mixing abnormalities (transposition of the great vessels, persistent truncus arteriosus, tetralogy of Fallot). The obstructive category included pulmonary valve stenosis, aortic valve stenosis, and coarctation of the aorta.
The haematocrit was divided into three levels: below 31 (‘anaemia’), 31–49 (‘normal’), and above 49 (‘polycythaemia’). The oxygen saturation was divided into two levels: ‘normal’ (90 and above), and ‘hypoxia’ (below 90). Statistical analysis was performed by one of us (KMK) using SPSS for Windows (SPSS Inc., Chicago, IL, USA) and the Pearson χ2 test.
Results
In all, 240 subjects were examined. Gender distribution was 53.3% male, racial composition was 100% white, and the median age was 1.0 year (mean=2.9 years; SD=4.2 years). Physiologically, the cardiac categories included volume overload in 90 (37.5%), cyanotic in 87 (36.3%), and obstructive in 63 (26.3%). The most common anatomic cardiac anomalies were ventricular or atrial septal defects (62), tetralogy of Fallot (39), pulmonary stenosis (25), and transposition of the great arteries (24). Other lesions included patent ductus arteriosus (13), double-outlet right ventricle (11), aortic stenosis (10), pulmonary atresia (10), coarctation of aorta (9), single ventricle (6), and atrio-ventricular canal (6). The mean oxygen saturation was 88% (SD=10), and the mean haematocrit was 39 (SD=8). A majority of patients with the cyanotic lesions tended to have polycythaemia, while a majority of subjects with volume overload tended to have anaemia (P=0.008). Hypoxia occurred in 22.4% of subjects with volume overload (some patients had pneumonia, endocarditis, high fever, or had already undergone cardiac surgery at the time of the eye exam), 43.5% of subjects with obstructive lesions, and 74.7% of subjects with cyanotic lesions (some cyanotic lesions had partial correction prior to admission) (P=0.000). A total of 81 subjects had undergone some type of surgical intervention prior to the eye exam.
In all, 105 subjects (43.7%) were syndromic, and these included velocardiofacial syndrome (18), Down's syndrome (17), CHARGE (coloboma, heart defect, atresia of choanae, retarded growth, genital hypoplasia, ear anomaly) association (6), DiGeorge syndrome (5), Williams syndrome, Edwards syndrome (trisomy 18), Noonan syndrome (3 each), VACTERL (vertebral, anal, cardiovascular, tracheo-oesophageal, renal, and limb defects) association, and Patau syndrome (trisomy 13) (2 each) (Table 1 ). The paediatric team recognized 51 syndromic patients, and the two geneticists identified the additional 54 syndromic patients.
Positive eye findings were present in 55% (132), and included retinal vascular tortuosity (46), optic nerve hypoplasia (30), trichomegaly (15), congenital ptosis (12) (bilateral in 7), squint (11), retinal haemorrhages (8), prominent eyes (7), cataract (6), nystagmus (4), megalopapilla (4), coloboma of optic disc or choroid (4), nasolacrimal duct obstruction (3), periorbital cyanosis (3), congenital glaucoma (2), and lens subluxation (2) (Tables 1 and 2 ). Cataract, ptosis, and strabismus occurred mainly in the syndromic population: eleven of twelve patients with ptosis, nine of eleven patients with strabismus, and five of six patients with cataract were syndromic (Table 1). High myopia (more than eight), high hyperopia (more than 6), and high astigmatism (more than 2) were present in four, six and 11 subjects, respectively. The mean spherical equivalent was +0.95 in the right eye (SD=3.2), and +0.97 in the left eye (SD=3.3). The mean astigmatism was 0.29 in the right eye (SD=0.60), and 0.31 in the left eye (SD=0.66).
There was a strong correlation between retinal vascular tortuosity and low haematocrit (P=0.000), and low arterial oxygen saturation (P=0.002). Cross-tabulation of the normal haematocrit group showed that retinal vascular tortuosity in that group was related to low oxygen saturation (Fisher's exact test P=0.028). Retinal vascular tortuosity was present in 11 subjects with the velocardiofacial syndrome: five of 11 had normal hematocrit and oxygen saturation. There was no relation between hyperopia and either retinal vascular tortuosity or optic nerve hypoplasia. In all, 10 subjects had both retinal vascular tortuosity and optic nerve hypoplasia (See Figures 1 and 2).
There was a correlation between the CHD anatomic types and syndromes. Syndromes were identified in 49% of those with tetralogy of Fallot (19/39) vs 28% of those with pulmonic stenosis (7/25), and 13% of those with transposition of great arteries (3/24) (P=0.008). There was no correlation between the CHD anatomic types and eye findings.
As a background, we present some epidemiological data on CHD in Lebanon (FFB, Children Cardiac Registry Center, AUB, Beirut, Lebanon; unpublished data collected prospectively from March 1997 till January 1999). The consanguinity among the parents was 32%. In all, 16% of patients had a family history of CHD. Maternal smoking was 35%, while paternal smoking was 54%. Maternal age distribution was as follows: In all, 11% were between 14–20 years, 68% between 21–30 years, and 21% between 31-42 years. The incidence of CHD in the medical centre was retrospectively 1.2% (27 CHD patients among 2345 live births at AUB medical centre during the year 1996).
Discussion
There is a high prevalence of associated syndromes with CHD in Lebanon (possibly from referral bias and high consanguinity) and around 50% of the involved syndromes can be missed without formal genetic consultation. There are several studies on the prevalence of individual chromosomal abnormalities, like 22q11.2 deletions31, 32, 33 (velocardiofacial and DiGeorge syndromes are due to 22q11.2 deletions). Borgmann et al31 found that routine screening for 22q11.2 deletions in nonsyndromic CHD subjects gave no yield. The morphological identification by geneticists is thereby emphasized.
The large percentage of ocular findings in CHD could be related to the high incidence of associated syndromes (Tables 1 and 2), to the possible embryologic link between the ocular and cardiac defect, or to the high incidence of consanguinity.
The present cross-sectional study underestimates the incidence of strabismus as half of the subjects were examined below age one. Gardiner and Joseph4 found strabismus in 14% of a total of 85 children with CHD, and amblyopia in 50% of patients with the tetralogy of Fallot. The present study did not measure intraocular pressure that can be elevated in some subjects with congestive heart failure.34, 35
Retinal vascular tortuosity is related to oxygen saturation and to certain syndromes (velocardiofacial syndrome). Pulsatile three-dimensional retinal arteriolar tortuosity has been previously reported in about 50% of patients with coarctation of the aorta.6 More recently, subjects with coarctation of the aorta have been found not to display these findings because of early surgical correction of the cardiac lesion, implying haemodynamic aetiology of vascular tortuosity.6 Similarly Crowe et al3, 8 showed that retinal vascular dilation and tortuosity in 14 subjects with cyanotic CHD decreased after surgical correction and seems related to the combination of polycythaemia and hypoxia. Petersen and Rosenthal5 found dilation and tortuosity of retinal vessels to be related to hypoxia and polycythaemia and to be present in nearly half of the patients (42 of 83) with cyanotic CHD. Analysis of our data suggests that subjects with high or low haematocrit develop tortuosity. In patients with normal haematocrit, low oxygen saturation or the presence of the velocardiofacial syndrome may account for the tortuosity.
Since there is a very high incidence of smoking in Lebanon,36 and a large number of patients were examined soon after birth, the effect of smoking mothers on the high incidence of retinal vascular tortuosity in neonates is to be considered. Beratis et al37 examined the retina of 162 neonates of smoking mothers and 162 matched neonates of nonsmoking mothers. Retinal venous dilatation and tortuosity was found in 100 and 36 eyes of neonates of smoking and nonsmoking mothers. Also, intraretinal haemorrhages were found in 61 and 31 eyes of neonates of smoking and nonsmoking mothers. All retinal abnormalities resolved by 6 months. Retinal vascular tortuosity may also be due congestive heart failure or rarely central retinal vein occlusion from cyanotic heart disease,28 or may be related to high hyperopia or an associated optic nerve hypoplasia.
Optic nerve hypoplasia38 is a congenital abnormality characterized by reduced number of axons in the optic nerve manifesting clinically as a small disc, often surrounded by a peripapillary halo (double-ring sign), and often accompanied by retinal vascular tortuosity. One-third of subjects (10 of 30) with optic nerve hypoplasia had retinal vascular tortuosity in the present study. Optic nerve hypoplasia was found to be associated with general disturbance in foetal development, young maternal age, first parity, maternal smoking, and preterm birth.38 The association of optic nerve hypoplasia with CHD is probably the result of a disturbance in early foetal development.
Coloboma is seen in many syndromes (trisomy 13 and 18, 4p-, cat's eye), in the CHARGE association, or in subjects with a normal karyotype. The highest incidence of coloboma among syndromes occurs in the CHARGE association (82%).39 Only 11% of patients with colobomas have the CHARGE association.15
The association of ptosis with CHD26 was first noted in 1986. Larned et al26 reviewed 156 cases of congenital ptosis and found seven nonsyndromic cases with CHD divided into pulmonic stenosis (three), ventricular septal defect (three), and patent ductus arteriosus (one). The authors noted that the frequency of CHD in the congenital ptosis study group was five times the expected frequency, and suggested an association between congenital ptosis and CHD. In the present study, congenital ptosis was present in 12 of 240 subjects, or 5%: three with velocardiofacial syndrome, two with Noonan syndrome, six cases with various syndromes, and one nonsyndromic. The present study confirmed the association of congenital ptosis with CHF in general, as the prevalence of congenital ptosis in the general population (0.18%)40 was 30 times lower than that the present series (5%).
Congenital cataract was present in six cases (2.5%): two with Down's syndrome, two with trisomy 13, one with Marfan syndrome, and one in a nonsyndromic patient. Wirth41 found Down's syndrome in 62% of a series of 29 syndromic congenital cataract cases. The prevalence of congenital cataract was 0.037% in the general population,41 68 times less than that in the present series (2.5%).
The distribution of refractive errors in CHD was quite similar to the normal distribution in healthy children from several continents.42, 43, 44, 45
Trichomegaly could be related to the high degree of consanguinity between the parents as suggested by Harrison and Mullaney46 and not part of a syndrome.
We had no case of bleeding tendency or venous stasis, and the instances of retinal haemorrhages could be related to sequelae of birth trauma, or severe cyanosis. Intraretinal haemorrhage was present in 34% of newborns, resolved within 4 weeks,47 and was more common in babies of smoking mothers.37
With modern interventional cardiac procedures, a large number of CHD subjects are expected to have a longer lifespan. Ophthalmologists will play an increasing role in the management of ocular diseases in this growing population, with emphasis on a multidisciplinary approach to the management of subjects with CHD.
References
Lewin MB . The genetic basis of congenital heart disease. Ped Annals 2000; 19: 469–480.
Goldmuntz E . The epidemiology and genetics of congenital heart disease. Clin in Perinatol 2001; 28: 1–10.
Kohner EM, Allen EM, Saunders KB, Emery VM, Pallis C . Electroencephalogram and retinal vessels in congenital cyanotic heart disease before and after surgery. Br Med J 1967; 4: 207–210.
Gardiner PA, Joseph M . Eye defects in children with congenital heart lesions: a preliminary study. Dev Med Child Neurol 1968; 10: 42–48.
Petersen RA, Rosenthal A . Retinopathy and papilledema in cyanotic heart disease. Pediatrics 1972; 49: 243–249.
Johns KJ, Johns JA, Feman SS . Retinal vascular abnormalities in patients with coarctation of the aorta. Arch Ophthalmol 1991; 109: 1266–1268.
Eisalo A, Raitta C, Kala R, Halonen PI . Fluorescence angiography of the fundus vessels in aortic coarctation. Br Heart J 1970; 32: 71–75.
Crowe RJ, Kohner EM, Owen SJ, Robinson DM . The retinal vessels in congenital heart disease. Med Biol 1969; 19: 95–99.
Mansour AM, Goldberg RB, Wang FM, Shprintzen RJ . Ocular findings in the velo-cardio-facial syndrome. J Ped Ophthalmol Strab 1987; 24: 263–266.
Traboulsi EI, Maumenee IH . Peters' anomaly and associated congenital malformations. Arch Ophthalmol 1992; 110: 1739–1742.
Gorlin RJ, Marashi AH, Obwegeser HL . Oculo-facio-cardio-dental (OFCD) syndrome. Am J Med Genet 1996; 63: 290–292.
Jackson L, Kline AD, Barr MA, Koch S . de Lange syndrome: a clinical review of 310 individuals. Am J Med Genet 1993; 47: 940–946.
Lee NB, Kelly L, Sharland M . Ocular manifestations of Noonan syndrome. Eye 1992; 6: 328–334.
Shulman SA, Hyams JS, Gunta R, Greenstein RM, Cassidy SB . Arteriohepatic dysplasia (Alagille syndrome): extreme variability among affected family members. Am J Med Genet 1984; 19: 325–332.
Chestler RJ, France TD . Ocular findings in CHARGE syndrome. Six case reports and a review. Ophthalmology 1988; 95: 1613–1619.
Cullum L, Liebman J . The association of congenital heart disease with Down's syndrome (mongolism). Am J Cardiol 1969; 24: 354.
Anderson M, Pratt-Thomas HR . Marfan's syndrome. Am Heart J 1953; 46: 911.
Frieden IJ, Reese V, Cohen D . PHACE syndrome. The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol 1996; 132: 307–311.
Mansour AM, Li H . Congenital cystic eye. Ophthalm Plastic Reconstr Surg 1996; 12: 104–107.
Greenberg F, Lewis RA . The Williams syndrome. Spectrum and significance of ocular features. Ophthalmology 1988; 95: 1608–1612.
Cruysberg JR, Draaijer RW, Pinckers A, Brunner HG . Congenital corneal anesthesia in children with the VACTERL association. Am J Ophthalmol 1998; 125: 96–98.
Brice G, Mansour S, Bell R, Collin JR, Child AH, Brady AF et al. Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J Med Genet 2002; 39: 478–483.
Green EK, Priestley MD, Waters J, Maliszewska C, Latif F, Maher ER . Detailed mapping of a congenital heart disease gene in chromosome 3p25. J Med Genet 2000; 37: 581–587.
Megarbane A, Salem N, Stephan E, Ashoush R, Lenoir D, Delague V et al. X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3. Eur J Hum Genet 2000; 8: 704–708.
Cunningham Jr ET, Eliott D, Miller NR, Maumenee IH, Green WR . Familial Axenfeld-Rieger anomaly, atrial septal defect, and sensorineural hearing loss. Arch Ophthalmol 1998; 116: 78–82.
Larned DC, Flanagan JC, Nelson LE, Harley RD, Wilson TW . The association of congenital ptosis and congenital heart disease. Ophthalmology 1986; 93: 492–494.
Beauchamp GR . Blepharophimosis and cardiopathy. J Pediatr Ophthalmol Strabismus 1980; 17: 227–228.
Vander Veen DK, Pasquale LR, Fulton AB . Central retinal vein occlusion in a young child with cyanotic heart disease. Arch Ophthalmol 1997; 115: 1077.
Schrire VS, Beck W, Chesler E . The heart and the eye. Am Heart J 1973; 85: 122–131.
Twelker JD, Mutti DO . Retinoscopy in infants using a near noncycloplegic technique, cycloplegia with tropicamide 1%, and cycloplegia with cyclopentolate 1%. Optom Vis Sci 2001; 78: 215–222.
Borgmann S, Luhmer I, Arslan-Kirchner M, Kallfelz HC, Schmidtke J . A search for chromosome 22q11.2 deletions in a series of 176 consecutively catheterized patients with congenital heart disease: no evidence for deletions in non-syndromic patients. Eur J Pediatr 1999; 158: 958–963.
Iserin L, de Lonlay P, Viot G, Sidi D, Kachaner J, Munnich A et al. Prevalence of the microdeletion 22q11 in newborn infants with congenital conotruncal cardiac anomalies. Eur J Pediatr 1998; 157: 881–884.
Fokstuen S, Arbenz U, Artan S, Dutly F, Bauersfeld U, Brecevic L et al. 22q11.2 deletions in a series of patients with non-selective congenital heart defects: incidence, type of defects and parental origin. Clin Genet 1998; 53: 63–69.
Horb ME, Thomsen GH . Tbx5 is essential for heart development. Development 1999; 126: 1739–1751.
Fu ER . Bilateral corkscrew episcleral veins from tricuspid incompetence. Am J Ophthalmol 1996; 122: 577–578.
Mansour AM, Shoughari AT, Ghazi NG, Mokdad F, Ghosn M . Health status of Lebanese ophthalmologists. Clin Exp Ophthalmol 2002; 30: 60–61.
Beratis NG, Varvarigou A, Katsibris J, Gartaganis SP . Vascular retinal abnormalities in neonates of mothers who smoked during pregnancy. J Pediatr 2000; 136: 760–766.
Tornqvist K, Ericsson A, Kallen B . Optic nerve hypoplasia: risk factors and epidemiology. Acta Ophthalmol Scand 2002; 80: 300–304.
Hayashi N, Valdes-Dapena M, Green WR . CHARGE association: histopathological report of two cases and a review. J Ped Ophthalmol Strab 1998; 35: 100–106.
Hu DN . Prevalence and mode of inheritance of major genetic eye diseases in China. J Med Genet 1987; 24: 584–588.
Wirth MG . Aetiology of congenital and paediatric cataract in an Australian population. Br J Ophthalmol 2002; 86: 782–786.
Mayer DL, Hansen RM, Moore BD, Kim S, Fulton AB . Cycloplegic refractions in healthy children aged 1 through 48 months. Arch Ophthalmol 2001; 119: 1625–1628.
Pokharel GP, Negrel AD, Munoz SR, Ellwein LB . Refractive error study in children: results from Mechi Zone, Nepal. Am J Ophthalmol 2000; 129: 436–444.
Zhao J, Pan X, Sui R, Munoz SR, Sperduto RD, Ellwein LB . Refractive error study in children: results from Shunyi District, China. Am J Ophthalmol 2000; 129: 427–435.
Maul E, Barroso S, Munoz SR, Sperduto RD, Ellwein LB . Refractive error study in children: results from La Florida, Chile. Am J Ophthalmol 2000; 129: 445–454.
Harrison DA, Mullaney PB . Familial trichomegaly. Arch Ophthalmol 1997; 115: 1602–1603.
Emerson MV, Pieramici DJ, Stoessel KM, Berreen JP, Gariano RF . Incidence and rate of disappearance of retinal hemorrhage in newborns. Ophthalmology 2001; 108: 36–39.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mansour, A., Bitar, F., Traboulsi, E. et al. Ocular pathology in congenital heart disease. Eye 19, 29–34 (2005). https://doi.org/10.1038/sj.eye.6701408
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.eye.6701408
Keywords
This article is cited by
-
Clinical and genetic findings in patients with congenital cataract and heart diseases
Orphanet Journal of Rare Diseases (2021)
-
Incidence of congenital heart diseases in Chinese children with non-syndromic congenital blepharoptosis: a prospective observational study of 1053 patients
World Journal of Pediatrics (2020)
-
Macular and peripapillary retinal nerve fibre layer thickness in patients with cyanotic congenital heart disease
Eye (2015)
-
MAPK activation in mature cataract associated with Noonan syndrome
BMC Ophthalmology (2013)
-
Spontaneous retinal venous pulsatility in patients with cyanotic congenital heart disease
Heart and Vessels (2012)