Abstract
OBJECTIVE: This study was conducted to examine the relation between iron status and neurobehavioral development in premature infants.
STUDY DESIGN: Infants born before 34 weeks postmenstrual age and who were medically stable were studied. Anemia was defined as hemoglobin ≤10 g/Dl and low iron stores as a serum ferritin concentration ≤75 μg/l. The infants were classified as anemic with low ferritin (Group 1; n=18), anemic with normal ferritin (Group 2; n=14), and nonanemic with normal ferritin (Group 3; n=21). A total of 18 reflexes were behaviorally evaluated at 37 weeks postmenstrual age and “reflex scores” were compared between the groups. Higher scores reflect a greater percentage of abnormal reflexes.
RESULTS: Infants in group 1 (anemia/low ferritin) had a significantly higher reflex score (51.45±18.32%) than infants in Group 3 (38.32±17.75%). Group 2 had an intermediate score (45.40±21.70%), but not different from the other two groups.
CONCLUSION: These data indicate that low iron status, both measured by anemia and ferritin levels, is related to poorer neurobehavioral status in premature infants.
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Supported in part by the Irving Harris Early Development Educational Program of the Shaare-Zedek Medical Center, Jerusalem, Israel.
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Armony-Sivan, R., Eidelman, A., Lanir, A. et al. Iron Status and Neurobehavioral Development of Premature Infants. J Perinatol 24, 757–762 (2004). https://doi.org/10.1038/sj.jp.7211178
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DOI: https://doi.org/10.1038/sj.jp.7211178
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