Abstract
Two cases of gestational choriocarcinoma have been examined for the expression of HLA and trophoblast antigens using the indirect immunoperoxidase technique on frozen tissue sections. Approximately 40-70% of tumour cells express MHC Class I antigen as detected by a panel of antibodies to monomorphic, or framework, MHC Class I antigenic determinants. Evidence in one case suggests that most of these cells may not express the paternal, polymorphic HLA antigenic determinants but that a small subpopulation do carry the fully antigenically active molecule. These latter may give rise to patient anti-paternal HLA antibodies. Class II (HLA DR or DC) antigens are expressed by none, or very few, tumour cells.
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Sunderland, C., Sasagawa, M., Kanazawa, K. et al. An immunohistological study of HLA antigen expression by gestational choriocarcinoma. Br J Cancer 51, 809–814 (1985). https://doi.org/10.1038/bjc.1985.126
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DOI: https://doi.org/10.1038/bjc.1985.126