Abstract
The aim of this study was to determine the concentration of PDGF in vivo in neoplastic and non-neoplastic brain lesions. Fluid from cystic lesions and cerebrospinal fluid was tested in a radioreceptor assay that detects all described PDGF isoforms. High concentration of PDGF were found in cyst fluids from several astrocytomas, one metastatic melanoma, one metastatic lung adenocarcinoma and one intracerebral abscess. The PDGF concentrations were several times higher than the levels known to be required for maximal PDGF effects on cells in vitro. PDGF could also be detected in some non-neoplastic lesions, especially one intracerebral abscess. The finding of high amounts of PDGF in neoplastic lesions strongly supports the possibility that PDGF can be a mediator of tumour and stromal cell growth and motility in vivo. Comparison of PDGF and beta-thromboglobulin concentrations in the same fluids strongly indicates that the PDGF protein is locally produced rather than a result of platelet activation and derangement of the blood-brain barrier.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nistér, M., Enblad, P., Bäckström, G. et al. Platelet-derived growth factor (PDGF) in neoplastic and non-neoplastic cystic lesions of the central nervous system and in the cerebrospinal fluid. Br J Cancer 69, 952–956 (1994). https://doi.org/10.1038/bjc.1994.184
Issue Date:
DOI: https://doi.org/10.1038/bjc.1994.184
This article is cited by
-
Cerebrospinal fluid stimulates leptomeningeal and meningioma cell proliferation and activation of STAT3
Journal of Neuro-Oncology (2012)
-
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
Journal of Molecular Medicine (2008)
-
New prospects for management and treatment of inoperable and recurrent skull base meningiomas
Journal of Neuro-Oncology (2008)
-
Platelet derived growth factor and subarachnoid haemorrage: A study on cisternal cerebrospinal fluid
Acta Neurochirurgica (1997)
-
Migration of human glioma cells in response to tumour cyst fluids
Acta Neurochirurgica (1996)