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Pediatric hematopoietic SCT in Mexico: recent activity and main problems

Bone Marrow Transplantation volume 46, pages 607–609 (2011)Cite this article

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Hematopoietic SCT (HSCT) has become an established therapy for numerous disorders of the hematopoietic system and for some solid tumors.1 However, owing to the high cost of the procedure, and the need for a multidisciplinary team, few centers in developing countries provide this treatment modality. In Mexico, the history of HSCT began in 1980, when the first transplant took place at the National Institute of Nutrition in Mexico City. After this, there were a few other procedures in the National Medical Center of the University Hospital of Monterrey, with poor results. This resulted in the suspension of the HSCT program at these institutions. As a result, the practice of HSCT in México was almost anecdotal until 1995.2 As there has been no national report, we consider it important to evaluate the current activity, needs and perspectives in the field of HSCT.

As there is no national database, only general information was requested from patients <18 years of age at the seven pediatric transplant centers for 2007 and 2008. The data requested were number of transplants per center, type of transplant, indication for allogeneic HSCT (allo-HSCT), indication for autologous HSCT (auto-HSCT), type of conditioning regimen, source of stem cells (BM, peripheral blood and cord blood), type of donor for allo-HSCT (matched sibling donor, unrelated donor and mismatched family donor). The total number of transplants was 127 (55 in 2007 and 72 in 2008) with a transplant rate of 1.57 and 2.05 per million population, respectively. Regarding the type of transplant, 22% of the children underwent auto-HSCT, whereas 78% underwent allo-HSCT. In the allo-HSCT group, 64.6% underwent transplantation for malignant diseases. The most common indication for auto-HSCT was AML. A myeloablative conditioning regimen was used in 54% of the allografts. Peripheral blood was the most common source of HSC. Among the recipients of allo-HSCT, the donor was a matched sibling donor in 62.6% of the cases (Table 1).

Table 1 Pediatric HSCT 2007–2008
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Authors and Affiliations

  1. Servicio de Hematología del Hospital Universitario ‘Dr José E. González’, Universidad Autónoma de Nuevo León, Monterrey, México

    L Rodríguez-Romo, O González-Llano, C Mancias-Guerra, J C Jaime-Pérez, A Gómez-Peña & D Gómez-Almaguer

  2. Centro de Hematología y Medicina Interna de Puebla, Clínica Ruíz, Puebla, México

    G Ruíz-Arguelles & G Ruíz-Delgado

  3. Servicio de Hematología y Oncología, Instituto Nacional de Pediatría, Ciudad de México, México

    A Olaya & A del Campo

  4. Servicio de Hematología y Oncología Pediátrica, Centro Médico La Raza, IMSS, Ciudad de México, México

    I Montero

  5. Servicio de Hematología y Oncología, Hospital Civil de Guadalajara, Jalisco, México

    O González-Ramella

  6. Servicio de Hematología, UMAE No. 25 IMSS, Monterrey, México

    A Sandoval, G González & T Pompa

  7. Centro de Trasplantes, Saltillo, México

    C Galindo

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  1. L Rodríguez-Romo
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  9. A del Campo
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  10. I Montero
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  13. G González
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  14. T Pompa
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  15. C Galindo
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  16. D Gómez-Almaguer
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Corresponding author

Correspondence to D Gómez-Almaguer.

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Rodríguez-Romo, L., González-Llano, O., Mancias-Guerra, C. et al. Pediatric hematopoietic SCT in Mexico: recent activity and main problems. Bone Marrow Transplant 46, 607–609 (2011). https://doi.org/10.1038/bmt.2010.151

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