Abstract
Although allogeneic hematopoietic cell transplantation (HCT) from a related donor is effective therapy for younger patients with AML, it remains unknown how the availability of a related donor affects the outcome when unrelated HCT is a treatment option for patients without a related donor. To address this issue, we retrospectively analyzed 605 cytogenetically non-favorable AML patients younger than 50 years for whom a related donor search was performed during first CR (CR1). The 4-year OS was 62% in 253 patients with a related donor and 59% in 352 patients without a related donor (P=0.534). Allogeneic HCT was performed during CR1 in 62% and 41% of patients with and without a related donor, respectively. Among patients transplanted in CR1, the cumulative incidence of non-relapse mortality was significantly higher in patients without a related donor (P=0.022), but there was no difference in post-transplant OS between the groups (P=0.262). These findings show the usefulness of unrelated HCT in younger patients with cytogenetically non-favorable AML who do not have a related donor. The extensive use of unrelated HCT for such patients may minimize the potential disadvantage of lacking a related donor.
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Acknowledgements
This work was supported by grants from the Japanese Ministry of Health, Labour and Welfare and the National Cancer Research and Development Fund (23-A-28).
Author contributions: MY designed the study, interpreted data, and wrote the manuscript; SK prepared the data file, performed the analysis and interpreted data; TY was primarily responsible for the study design, data analysis and interpretation of the data; NU, SM, HK, KU, TK, MW, KN, SY, Y Nawa, JT, HT, Y Nakamura, SF and FK obtained the patients’ data and interpreted data; NE designed the study and interpreted data; IM reviewed the cytogenetic reports and interpreted data; and TF interpreted data and helped to write the manuscript.
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Yanada, M., Kurosawa, S., Yamaguchi, T. et al. Effect of related donor availability on outcome of AML in the context of related and unrelated hematopoietic cell transplantation. Bone Marrow Transplant 48, 390–395 (2013). https://doi.org/10.1038/bmt.2012.159
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DOI: https://doi.org/10.1038/bmt.2012.159
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