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Macrophages are the main effectors of the innate immune response and are programmed to detect and eliminate diseased cells including cells with mutated genomes. Solid tumours can co-opt these innate immune cells, including infiltrating macrophages, and promote a change in their phenotype to pro-tumorigenic tumour-associated macrophages (M2-TAMs), which induce immune suppression. To circumvent this M2-TAM-mediated immune evasion by tumours, Jaynes et al. identified a peptide that reprogrammes M2-TAMs to exhibit antitumour activity as observed by M1-like TAMs (M1-TAMs) in vivo. This innate immune response-enabled antitumour activity was observed in mouse models across different cancer types and was enhanced in combination with PD-L1 checkpoint inhibition in a pancreatic cancer model.
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Nature Reviews Drug Discovery19, 236 (2020)
doi: https://doi.org/10.1038/d41573-020-00040-0
References
Jaynes, J. M. et al. Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses. Sci. Transl Med.12, eaax6337 (2020)