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Metabolism reprogrammed by the nitric oxide signalling molecule

The signalling molecule nitric oxide protects the kidneys by reprogramming metabolism, and its levels are regulated by a two-component system in mice. These findings identify new targets for drug discovery.
  1. Charles J. Lowenstein

    1. Charles J. Lowenstein is in the Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, USA.

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Acute kidney injury can lead to chronic renal failure, which causes fluid and electrolyte imbalances in the blood that require dialysis. Such injuries commonly involve ischaemia–reperfusion events, in which the blood supply to the kidney is temporarily restricted but then restored; this process generates toxic oxygen radicals that can cause renal inflammation and damage. Writing in Nature, Zhou et al.1 report that the signalling molecule nitric oxide2,3 reprograms a metabolic pathway, and thereby limits ischaemic injury and protects renal function.

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Nature 565, 33-34 (2019)

doi: https://doi.org/10.1038/d41586-018-07457-z

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