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A proton-pumping enzyme in the brain switches between modes

The enzyme V-ATPase pumps protons into vesicles at the synaptic connections between neuronal cells, and is crucial for neuronal communication. Observations of individual V-ATPase molecules reveal that they randomly switch between proton-pumping, rest and leaking modes, which each last for several minutes, with potential implications for neurotransmission.

This is a summary of: Kosmidis, E. et al. Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching. Nature 611, 827–834 (2022).

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doi: https://doi.org/10.1038/d41586-022-03617-4

‘Expert opinion’ is published under a CC BY 4.0 licence.

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