Abstract
Three new α-class milbemycins from Streptomyces bingchenggensis, named milbemycins α28, α29 and α30, have been isolated and characterized. On the basis of detailed spectroscopic analysis and comparison with reported data, their structures were determined to be the 22α-hydroxy, 23β-O-(2-methylbutanoyl) milbemycin α9, 22α-hydroxy, 23β-O-(2,4-dimethylpentanoyl) milbemycin α9 and 22α-hydroxy, 23β-O-(2-methylbutanoyl) milbemycin A4, respectively. Milbemycins α28 and α29 are the first reported milbemycins that possess both C-26 and C-23 substituents. These three new milbemycins possess potent acaricidal and nematocidal activity.
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Xiang, WS., Wang, JD., Wang, XJ. et al. Further New Milbemycin Antibiotics from Streptomyces bingchenggensis. J Antibiot 60, 608–613 (2007). https://doi.org/10.1038/ja.2007.78
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DOI: https://doi.org/10.1038/ja.2007.78
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