Abstract.
The incidence of congenital preauricular fistula (CPF) is >1.1% in both Chinese and Caucasians, but it is even higher in Blacks. We mapped the locus for CPF to chromosome 8q11.1–q13.3 by linkage analysis of a family composed of 7 affected and 11 nonaffected members. The two-point LOD score was 2.40, shown by markers D8S285 and D8S1113 at a recombination fraction (θ) of 0.00. Results from three other markers (D8S1110, D8S260, and D8S1136) in the same region further support the linkage. Haplotype analysis for this family confined the locus to within an interval of approximately 26.7 cM, flanked by markers D8S532 and D8S279. A LOD score of <3 is likely due to the limitation of family size.
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Received: October 16, 2002; Accepted: November 25, 2002
Acknowledgments We would like to thank Shanghai Municipal Commission for Science and Technology, the National Natural Science Foundation of China, and the National 973 and 863 Projects for their generous financial support of this study.
The first and third authors contributed equally to this work.
Correspondence to:L. He
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Zou, F., Peng, Y., Wang, X. et al. A locus for congenital preauricular fistula maps to chromosome 8q11.1–q13.3. J Hum Genet 48, 155–158 (2003). https://doi.org/10.1007/s100380300024
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DOI: https://doi.org/10.1007/s100380300024
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