Abstract.
 The angiopoietins are an important family of growth factors specific for vascular endothelium. Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 (ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.
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Received: November 22, 2002 / Accepted: December 11, 2002
The first two authors contributed equally to this work.
Correspondence to:Y. Mao
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Zeng, L., Dai, J., Ying, K. et al. Identification of a novel human angiopoietin-like gene expressed mainly in heart. J Hum Genet 48, 159–162 (2003). https://doi.org/10.1007/s100380300025
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DOI: https://doi.org/10.1007/s100380300025
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