Abstract
The coexistence of duodenal atresia (DA) may mask the antenatal ultrasound findings of meconium ileus (MI) and delay its postnatal diagnosis. We report a rare case of MI in a newborn infant diagnosed antenatally to have trisomy 21 and DA. The diagnosis of MI was only established intraoperatively after the patient showed persistent signs of intestinal obstruction following the surgical repair of the DA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Park RW, Grand RJ . Gastrointestinal manifestation of cystic fibrosis: a review. Gastroenterology 1961; 81: 1143–1161.
Scotet V, Dugueperoux I, Audrezet MP, Audebert-Bellanger S, Muller M, Blayau M et al. Focus on cystic fibrosis and other disorders evidenced in fetuses with sonographic finding of echogenic bowel: 16-year report from Brittany, France. Am J Obstet Gynecol 2010; 203: 592.e1–6.
Bahado-Singh R, Morotti R, Copel JA, Mahoney MJ . Hyperechoic fetal bowel: the perinatal consequences. Prenat Diagn 1994; 14: 981–987.
Carlyle BE, Borowitz DS, Glick PL . A review of pathophysiology and management of fetuses and neonates with meconium ileus for the pediatric surgeon. J Pediatr Surg 2012; 47 (4): 772–781.
O’Rahilly R, Muller F . Human Embryology and Teratology. Wiley-Liss: New York, 1996 p 229.
Louw JH, Barnard CN . Congenital intestinal atresia; observations on its origin. Lancet 1955; 269 (6899): 1065–1067.
Fonkalsrud EW, de Lorimer AA, Hays DM . Congenital atresia and stenosis of the duodenum: a review compiled from the members of the surgical section. Am Acad Pediatr 1969; 43: 79–83.
Choudhry MS, Rahman N, Boyd P, Lakhoo K . Duodenal atresia: associated anomalies, prenatal diagnosis and outcome. Pediatr Surg Int 2009; 25 (8): 727–730.
Rapoport S, Buchanan DJ . The composition of meconium; isolation of blood-group-specific polysaccharides; abnormal compositions of meconium in meconium ileus. Science 1950; 112 (2901): 150–153.
Guy EL, Peckham DG, Brownlee KG, Conway SP, Lee TW . Cystic fibrosis co-existing with trisomy 21. J Cyst Fibros. 2010; 9 (5): 330–331.
Milunsky A . Cystic fibrosis and Down's syndrome. Pediatrics 1968; 42: 501–504.
Vetrella M, BartheImai W, Matsuda H . Down's syndrome and cystic fibrosis. Pediatrics 1969; 43: 905–906.
Kruger C, Barmeier H, Sailer R, Harms D . Cystic fibrosis in Down's syndrome-diagnostic pitfalls and implications for the clinician. Arch Dis Child 1998; 78: 194.
Munck A, Gerardin M, Alberti C, Ajzenman C, Lebourgeois M, Aigrain Y et al. Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. J Pediatr Surg 2006; 41: 1556–1560.
Efrati O, Nir J, Fraser D, Cohen-Cymberknoh M, Shoseyov D, Vilozni D et al. Meconium ileus in patients with cystic fibrosis is not a risk factor for clinical deterioration and survival: the Israeli Multicenter Study. J Pediatr Gastroenterol Nutr 2010; 50: 173–178.
Johnson JA, Bush A, Buchdahl R . Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis? Pediatr Pulmonol 2010; 45: 951–958.
Acknowledgements
Dr Olusegun Akinloye wrote the first draft of the manuscript. This project was conducted with no specific financial support. No honorarium, grant or other form of payment was given to anyone to produce this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Akinloye, O., Truong, W., Giacomantonio, M. et al. Coexistence of meconium ileus with duodenal atresia and trisomy 21 in a newborn: a case report. J Perinatol 34, 875–876 (2014). https://doi.org/10.1038/jp.2014.124
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/jp.2014.124