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Notch inhibition blocks multiple myeloma cell-induced osteoclast activation

Leukemia volume 22, pages 2273–2277 (2008)Cite this article

Our data provide first-time evidence that Notch signaling is involved in specific tumor–stroma interactions between MM cells and primary OCL through direct cell–cell contact. We further demonstrate that this interaction is specific for OCL, as Notch signaling in OBL and MSC remains unaffected. Given that our findings in vitro are confirmed in myeloma models in vivo, use of GSI might become a novel therapeutic option in MM as we could demonstrate that they have antitumor effects (apoptosis induction) and suppress Notch-dependent OCL activity.

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Acknowledgements

We thank Katharina Kley for excellent technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft Klinische Forschergruppe KFO 105 (UH, OS, BD, FJ) and SFB 449 (RP), and from the Deutsche Krebshilfe 10-6930 (RP).

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Authors and Affiliations

  1. Department of Hematology and Oncology, Charité, Campus Virchow-Klinikum, University Medicine, Berlin, Germany

    R Schwarzer, O Acikgoez, S Mathas, B Doerken & F Jundt

  2. Department of Oncology and Hematology, Charité, Campus Mitte, University Medicine, Berlin, Germany

    M Kaiser, U Heider & O Sezer

  3. Max Delbrück Center for Molecular Medicine, Berlin, Germany

    O Acikgoez, S Mathas, B Doerken & F Jundt

  4. Institute of Molecular Biology and Bioinformatics, Charité, Campus Benjamin Franklin, University Medicine, Berlin, Germany

    R Preissner

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  1. R Schwarzer
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  2. M Kaiser
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  3. O Acikgoez
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  4. U Heider
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  5. S Mathas
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  7. O Sezer
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  8. B Doerken
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  9. F Jundt
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Correspondence to F Jundt.

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Schwarzer, R., Kaiser, M., Acikgoez, O. et al. Notch inhibition blocks multiple myeloma cell-induced osteoclast activation. Leukemia 22, 2273–2277 (2008). https://doi.org/10.1038/leu.2008.138

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