This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ambrosini G, Adida C, Altieri DC . A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997; 8: 917–921.
Altznauer F, Martinelli S, Yousefi S, Thürig C, Schmid I, Conway EM et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med 2004; 199: 1343–1354.
Tamm I, Richter S, Oltersdorf D, Creutzig U, Harbott J, Scholz F et al. High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res 2004; 10: 3737–3744.
Carlsson G, Aprikyan AA, Tehranchi R, Dale DC, Porwit A, Hellström-Lindberg E et al. Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Blood 2004; 103: 3355–3361.
Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schäffer AA et al. HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet 2007; 39: 86–92.
Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K et al. LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med 2006; 12: 1191–1197.
Fukuda S, Pelus LM . Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis. Blood 2001; 98: 2091–2100.
Carter BZ, Milella M, Altieri DC, Andreeff M . Cytokine-regulated expression of survivin in myeloid leukemia. Blood 2001; 97: 2784–2790.
Acknowledgements
This study was supported by the Swedish Cancer Foundation, Swedish Children's Cancer Foundation, Lars Hierta Memorial Foundation and Stockholm County Council (ALF Project).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Carlsson, G., Boxhammer, S., Garwicz, D. et al. Survivin expression in the bone marrow of patients with severe congenital neutropenia. Leukemia 23, 622–625 (2009). https://doi.org/10.1038/leu.2008.258
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2008.258
This article is cited by
-
Severe congenital neutropenias
Nature Reviews Disease Primers (2017)