This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rubnitz JE . Childhood acute myeloid leukemia. Curr Treat Options Oncol 2008; 9: 95–105.
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361: 1058–1066.
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321: 1807–1812.
Ho PA, Alonzo TA, Kopecky KJ, Miller KL, Khun J, Zeng R et al. Molecular alterations of the IDH1 gene in AML: a Children's oncology group and southwest oncology group study. Leukemia 2010; 24: 909–913.
Wagner K, Damm F, Gòhring G, Gòrlich K, Heuser M, Schlàfer I et al. Impact of IDH1 R132 mutations and an Idh1single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol 2010; 28: 2356–2364.
Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 2009; 324: 261–265.
Chou WC, Hou HA, Chen CY, Tang JL, Yao M, Tsay W et al. Distinct clinical and biological characteristics in adult acute myeloid leukemia bearing isocitrate dehydrogenase 1 (IDH1) mutation. Blood 2010; 115: 2749–2754.
Acknowledgements
This work was supported by Comitato ML Verga and Fondazione Tettamanti (Monza), Fondazione Città della Speranza (Padova), Associazione Italiana per la Ricerca sul Cancro (AIRC), Fondazione Cariplo, Ministero dell'Istruzione and Università e Ricerca (MIUR). We thank Vincenzo Rossi, Dr Sabrina Gelain and Dr Alessandra Beghin for their excellent technical support.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Pigazzi, M., Ferrari, G., Masetti, R. et al. Low prevalence of IDH1 gene mutation in childhood AML in Italy. Leukemia 25, 173–174 (2011). https://doi.org/10.1038/leu.2010.229
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2010.229
This article is cited by
-
Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML
Leukemia (2018)
-
A somatic EZH2 mutation in childhood acute myeloid leukemia
Leukemia (2012)
-
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups
Leukemia (2011)