Abstract
Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL.
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Acknowledgements
The paper summarizes data discussed on the occasion of the NLLLN Meeting Primary CNS Lymphoma—Neuropathology & Differential Diagnosis—Biology & Genetics held in Cologne, 15 January 2010. NLLLN is member of KML. This study was supported by the Deutsche Krebshilfe/Dr Mildred Scheel Stiftung für Krebsforschung (Grant no. 109471) and the Deutsche Forschungsgemeinschaft (De 485/9-1).
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Deckert, M., Engert, A., Brück, W. et al. Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma. Leukemia 25, 1797–1807 (2011). https://doi.org/10.1038/leu.2011.169
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DOI: https://doi.org/10.1038/leu.2011.169
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