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References
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. International Agency for Research on Cancer (IARC): Lyon, 2008.
Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Oncologist 2006; 11: 263–273.
Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmaki H, Andersson EI et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012; 366: 1905–1913.
Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Ng KP et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T cell large granular lymphocyte leukemia. Blood 2012; 120: 3048–3057.
Kern W, Bacher U, Haferlach C, Alpermann T, Dicker F, Schnittger S et al. Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia. Cytometry B Clin Cytom 2012; 82: 145–150.
van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257–2317.
Lamy T, Loughran TP Jr. How I treat LGL leukemia. Blood 2011; 117: 2764–2774.
Sosin MD, Handa SI . Spontaneous remission of large granular lymphocytic leukaemia. Int J Clin Pract 2003; 57: 551–552.
Shichishima T, Kawaguchi M, Ono N, Oshimi K, Nakamura N, Maruyama Y . Gammadelta T-cell large granular lymphocyte (LGL) leukemia with spontaneous remission. Am J Hematol 2004; 75: 168–172.
Acknowledgements
We thank all clinicians for sending samples to our laboratory for diagnostic purposes, and for providing clinical information and follow-up data. In addition, we would like to thank all co-workers at the MLL Munich Leukemia Laboratory for approaching together many aspects in the field of leukemia diagnostics and research. In addition, we are grateful for the data management support performed by Tamara Alpermann.
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WK, CH, TH and SS are part owners of the MLL Munich Leukemia Laboratory. AF and VG are employed by the MLL Munich Leukemia Laboratory.
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Fasan, A., Kern, W., Grossmann, V. et al. STAT3 mutations are highly specific for large granular lymphocytic leukemia. Leukemia 27, 1598–1600 (2013). https://doi.org/10.1038/leu.2012.350
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DOI: https://doi.org/10.1038/leu.2012.350
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