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References
Mitelman F, Johansson B, Mertens F Mitelman database of chromosome aberrations in cancer 2013. http://cgap.nci.nih.gov/Chromosomes/Mitelman.
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001; 344: 1038–1042.
Warrell RP, Frankel SR, Miller WH, Scheinberg DA, Itri LM, Hittelman WN et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 1991; 324: 1385–1393.
Pui C-H, Relling MV, Downing JR . Acute lymphoblastic leukemia. N Engl J Med 2004; 350: 1535–1548.
Mrózek K, Heerema NA, Bloomfield CD . Cytogenetics in acute leukemia. Blood Rev 2004; 18: 115–136.
Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P et al. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. Haematologica 2010; 95: 20–26.
Iyer MK, Chinnaiyan AM, Maher CA . ChimeraScan: a tool for identifying chimeric transcription in sequencing data. Bioinformatics 2011; 27: 2903–2904.
Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059–2074.
Toffalini F, Demoulin J-B . New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases. Blood 2010; 116: 2429–2437.
Mossadegh-Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley ER, Nutt SL et al. M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature 2013; 497: 239–243.
Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA . FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci USA 1990; 87: 1377–1380.
Gu T, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG et al. A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 2007; 110: 323–333.
Chase A, Schultheis B, Kreil S, Baxter J, Hidalgo-Curtis C, Jones A et al. Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1. Leukemia 2008; 23: 358–364.
Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells. Nat Med 1996; 2: 561–566.
Conway JG, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci USA 2005; 102: 16078–16083.
Acknowledgements
This work was supported by the Swedish Cancer Society, the Swedish Children’s Cancer Foundation, the Inga-Britt and Arne Lundberg Foundation, the Gunnar Nilsson Cancer Foundation, the Medical Faculty of Lund University and the Swedish Research Council (personal project grant to TF, Hemato-Linné and BioCARE strategic research program grants).
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Lilljebjörn, H., Ågerstam, H., Orsmark-Pietras, C. et al. RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib. Leukemia 28, 977–979 (2014). https://doi.org/10.1038/leu.2013.324
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DOI: https://doi.org/10.1038/leu.2013.324
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