Abstract
Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.
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Acknowledgements
The author thanks M. Wu and R. Luik for stimulating discussions throughout the course of this work. This work was supported by a grant from the NIGMS and the Mathers Charitable Foundation.
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Lewis, R. The molecular choreography of a store-operated calcium channel. Nature 446, 284–287 (2007). https://doi.org/10.1038/nature05637
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DOI: https://doi.org/10.1038/nature05637
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