Antibiotic-tolerant, dormant variants of otherwise antibiotic-sensitive bacteria underlie many chronic and relapsing infections. A small molecule has been identified that can efficiently eradicate these persister cells. See Article p.365
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References
Lewis, K. Annu. Rev. Microbiol. 64, 357–372 (2010).
Conlon, B. P. et al. Nature 503, 365–370 (2013).
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L. & Leibler, S. Science 305, 1622–1625 (2004).
Maisonneuve, E., Castro-Camargo, M. & Gerdes, K. Cell 154, 1140–1150 (2013).
Veening, J. W., Smits, W. K. & Kuipers, O. P. Annu. Rev. Microbiol. 62, 193–210 (2008).
Dalebroux, Z. D. & Swanson, M. S. Nature Rev. Microbiol. 10, 203–212 (2012).
Brötz-Oesterhelt, H. et al. Nature Med. 11, 1082–1087 (2005).
Baker, T. A. & Sauer, R. T. Biochim. Biophys. Acta 1823, 15–28 (2012).
Frees, D., Savijoki, K., Varmanen, P. & Ingmer, H. Mol. Microbiol. 63, 1285–1295 (2007).
Li, D. H. et al. Chem. Biol. 17, 959–969 (2010).
Lee, B. G. et al. Nature Struct. Mol. Biol. 17, 471–478 (2010).
Leung, E. et al. Chem. Biol. 18, 1167–1178 (2011).
Sowole, M. A., Alexopoulos, J. A., Cheng, Y. Q., Ortega, J. & Konermann, L. J. Mol. Biol. 425, 4508–4519 (2013).
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Gerdes, K., Ingmer, H. Killing the survivors. Nature 503, 347–349 (2013). https://doi.org/10.1038/nature12834
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DOI: https://doi.org/10.1038/nature12834