Light isotopes of hydrogen and helium formed minutes after the Big Bang. The study of one of these primordial isotopes, helium-3, has now been proposed as a useful strategy for constraining the physics of the standard cosmological model.
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Prantzos, N. Rare isotopic insight into the Universe. Nature 529, 33–34 (2016). https://doi.org/10.1038/nature16326
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DOI: https://doi.org/10.1038/nature16326