Abstract
Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
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Acknowledgements
We thank members of the Thompson laboratory and in particular L. Finley and T. Lindsten for discussions. W.P. is the recipient of the Genentech Foundation Hope Funds for Cancer Research Fellowship. Work in the Thompson laboratory is supported by a grant from NCI to C.B.T. (R01 CA201318) and Cancer Center Support Grant P30CA008748.
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W.P. and C.B.T. conceived and wrote the manuscript.
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C.B.T. is a founder of Agios Pharmaceuticals and a member of its scientific advisory board. C.B.T. also serves on the board of directors of Merck and Charles River Laboratories.
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Palm, W., Thompson, C. Nutrient acquisition strategies of mammalian cells. Nature 546, 234–242 (2017). https://doi.org/10.1038/nature22379
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DOI: https://doi.org/10.1038/nature22379
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