Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

T-cell transfer therapy targeting mutant KRAS in cancer

Tran, E. et al. N. Engl. J. Med. 375, 2255–2262 (2016)

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

Dewey, F.E. et al. Science 354, aaf6814 (2016)

Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens

Dixit, A. et al. Cell 167, 1853–1866.e17 (2016)

A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response

Adamson, B. et al. Cell 167, 1867–1882.e21 (2016)

Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNA-seq

Jaitin, D.A. et al. Cell 167, 1883–1896.e15 (2016)