Successful animal cloning after nuclear transfer requires efficient reprogramming to achieve totipotency. Erasure of pre-existing marks is not always efficient and some genes can escape reprogramming and maintain their original active transcriptional state. Ng and Gurdon propose that the histone H3.3 variant is a key player in this process.
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Lacoste, N., Almouzni, G. Epigenetic memory: H3.3 steps in the groove. Nat Cell Biol 10, 7–9 (2008). https://doi.org/10.1038/ncb0108-7
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DOI: https://doi.org/10.1038/ncb0108-7
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