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Mitochondria get a Parkin' ticket

Nature Cell Biology volume 12, pages 104–106 (2010)Cite this article

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Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

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Figure 1: Model of PINK1/Parkin-mediated mitophagy.

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  1. Philipp Wild and Ivan Dikic are at the Goethe University Medical School, Institute of Biochemistry II and Frankfurt Institute for Molecular Life Sciences, Theodor-Stern-Kai 7, Frankfurt a.M., D-60590, Germany.,

    Philipp Wild & Ivan Dikic

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  1. Philipp Wild
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  2. Ivan Dikic
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Correspondence to Ivan Dikic.

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Wild, P., Dikic, I. Mitochondria get a Parkin' ticket. Nat Cell Biol 12, 104–106 (2010). https://doi.org/10.1038/ncb0210-104

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