Semaphorins regulate a variety of biological processes, including axon guidance, neuronal migration, angiogenesis, cardiogenesis and immune responses. Semaphorin 6D is now shown to regulate osteoclast function during bone development, through its association with its receptor plexinA1. This activity implicates a signalling pathway known to transcriptionally regulate cell differentiation and involves the receptor Trem2 and the adaptor DAP12.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation
Cell & Bioscience Open Access 08 November 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
R. P., Kruger, Aurandt, J. & Guan, K.-L. Nature Rev. Mol. Cell Biol. 6, 789–800 (2005).
Tamagnone, L. & Comoglio, P.M. EMBO Rep. 5, 356–361 (2004).
Takegahara, N. et al. Nature Cell Biol. 8, 615–622 (2006).
Oinuma, I., Ishikawa, Y., Katoh, H. & Negishi, M., Science 305, 862–865 (2006).
Comeau, M. et al. Immunity 4, 473–482 (1998).
Hall, K.T. et al. Proc. Natl Acad. Sci. USA 93, 11780–11785 (1996).
Shi, W. et al. Immunity 13, 633–642 (2000).
Kikutani, H. & Kumanogoh, A. Nature Rev. Immunol. 2, 159–167 (2003).
Wong, A.W. et al. Nature Immunol. 9, 891–898 (2003).
Toyofuku, T. et al. Nature Cell Biol. 6, 1204–1211 (2004).
Kaifu, O. et al. J. Clin. Invest. 111, 323–332 (2003).
Humphrey, M.B., Lanier L.L. & Nakamura, M.C. Immunol. Rev. 208, 50–65 (2005).
Colonna, M. Nature Rev. Immunol. 3, 1–9 (2203)
Koga, T. et al. Nature 428, 758–763 (2004).
Toyofuku, T. et al. Genes Dev. 18, 435–447 (2004).
Kumanogoh, A. et al. Immunity 13, 621–631 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tamagnone, L., Giordano, S. Semaphorin pathways orchestrate osteogenesis. Nat Cell Biol 8, 545–547 (2006). https://doi.org/10.1038/ncb0606-545
Issue Date:
DOI: https://doi.org/10.1038/ncb0606-545
This article is cited by
-
An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation
Cell & Bioscience (2022)
-
Cellular communications in bone homeostasis and repair
Cellular and Molecular Life Sciences (2010)
-
Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive
EMBO reports (2008)
-
The TREM receptor family and signal integration
Nature Immunology (2006)