Abstract
Despite a growing appreciation of functional analogies between visual and hormonal signalling systems in the early 1980s, the discovery of the close structural relationship between rhodopsin and the β2-adrenergic receptor, and of the existence of a larger ‘superfamily’ of such receptors, came as a total surprise. Here I provide a personal perspective on events leading up to and flowing from this exciting discovery that opened up a vast field of research.
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This work was supported in part by the National Institutes of Health Grant HL 16037.
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Lefkowitz, R. The superfamily of heptahelical receptors . Nat Cell Biol 2, E133–E136 (2000). https://doi.org/10.1038/35017152
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DOI: https://doi.org/10.1038/35017152
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