In endocrine cells, secretion can be rapidly upregulated in response to stimuli without the need for additional synthesis of transport components. A new and unexpected function of KDEL-R as a signalling receptor that senses cargo protein load in the early secretory pathway has been identified.
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Asp, L., Nilsson, T. Golgi gets wired up. Nat Cell Biol 10, 885–887 (2008). https://doi.org/10.1038/ncb0808-885
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DOI: https://doi.org/10.1038/ncb0808-885